L227-0490 Screening compound: 1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-N-(2-methoxy-5-methylphenyl)piperidine-4-carboxamide

L227-0490 Screening compound: 1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-N-(2-methoxy-5-methylphenyl)piperidine-4-carboxamide
L227-0490 Screening compound: 1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-N-(2-methoxy-5-methylphenyl)piperidine-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L227-0490
1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-N-(2-methoxy-5-methylphenyl)piperidine-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L227-0490

Molecular Formula

C27H28FN5O2 (C27 H28 FN5 O2)

Compound Name

1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]-N-(2-methoxy-5-methylphenyl)piperidine-4-carboxamide

IUPAC name

1-[2-(4-fluorophenyl)-5-methylpyrazolo[15-a]pyrimidin-7-yl]-N-(2-methoxy-5-methylphenyl)piperidine-4-carboxamide

SMILES

Cc(cc1)cc(NC(C(CC2)CCN2c2cc(C)nc3cc(-c(cc4)ccc4F)nn23)=O)c1OC

InChI

InChI=1S/C27H28FN5O2/c1-17-4-9-24(35-3)23(14-17)30-27(34)20-10-12-32(13-11-20)26-15-18(2)29-25-16-22(31-33(25)26)19-5-7-21(28)8-6-19/h4-9,14-16,20H,10-13H2,1-3H3,(H,30,34)

InChI Key

SIDIAMZPCXZCQE-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27236536

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

473.55

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.907

Distribution Coefficient, logD

2.753

Water Solubility, LogSw

-4.66

Polar Surface Area

51.757

Acid Dissociation Constant (pKa)

10.81

Base Dissociation Constant (pKb)

9.55

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

29.60

L227-0490 in Drug Discovery

Included in Screening Libraries

Macl-GPIb alpha Interaction Library (22969 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Ion Channels Focused Library (26372 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Hemic and lymphatic
  • Cardiovascular
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
  • Nervous system
  • Cardiovascular
Targets:
  • Kinases
  • Ion Channels

References: we are preparing a list of scientific research reports with L227-0490 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L227-0490?
Check Price and Availability of L227-0490, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L227-0490 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L227-0490
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L227-0490
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L227-0490 available by request