L227-0512 Screening compound: N-[2-(azepan-1-yl)ethyl]-1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]piperidine-4-carboxamide

L227-0512 Screening compound: N-[2-(azepan-1-yl)ethyl]-1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]piperidine-4-carboxamide
L227-0512 Screening compound: N-[2-(azepan-1-yl)ethyl]-1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]piperidine-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L227-0512
N-[2-(azepan-1-yl)ethyl]-1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]piperidine-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L227-0512

Molecular Formula

C27H35FN6O (C27 H35 FN6 O)

Compound Name

N-[2-(azepan-1-yl)ethyl]-1-[2-(4-fluorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-7-yl]piperidine-4-carboxamide

IUPAC name

N-[2-(azepan-1-yl)ethyl]-1-[2-(4-fluorophenyl)-5-methylpyrazolo[15-a]pyrimidin-7-yl]piperidine-4-carboxamide

SMILES

Cc1nc2cc(-c(cc3)ccc3F)nn2c(N(CC2)CCC2C(NCCN2CCCCCC2)=O)c1

InChI

InChI=1S/C27H35FN6O/c1-20-18-26(34-25(30-20)19-24(31-34)21-6-8-23(28)9-7-21)33-15-10-22(11-16-33)27(35)29-12-17-32-13-4-2-3-5-14-32/h6-9,18-19,22H,2-5,10-17H2,1H3,(H,29,35)

InChI Key

AVVGEJRHVCXDPY-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15120619

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

478.61

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.375

Distribution Coefficient, logD

2.221

Water Solubility, LogSw

-4.04

Polar Surface Area

50.302

Acid Dissociation Constant (pKa)

13.35

Base Dissociation Constant (pKb)

9.55

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

51.90

L227-0512 in Drug Discovery

Included in Screening Libraries

GPCR Targeted Library (31838 compounds)

MCL1 Targeted Library (12200 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • GPCR
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with L227-0512 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L227-0512?
Check Price and Availability of L227-0512, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L227-0512 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L227-0512
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L227-0512
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L227-0512 available by request