L244-0143 Screening compound: N-[3-(azepan-1-yl)propyl]-1-{5-oxo-5H,6H,7H,8H,9H-[1,3,4]thiadiazolo[2,3-b]quinazolin-2-yl}piperidine-3-carboxamide

L244-0143 Screening compound: N-[3-(azepan-1-yl)propyl]-1-{5-oxo-5H,6H,7H,8H,9H-[1,3,4]thiadiazolo[2,3-b]quinazolin-2-yl}piperidine-3-carboxamide
L244-0143 Screening compound: N-[3-(azepan-1-yl)propyl]-1-{5-oxo-5H,6H,7H,8H,9H-[1,3,4]thiadiazolo[2,3-b]quinazolin-2-yl}piperidine-3-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L244-0143
N-[3-(azepan-1-yl)propyl]-1-{5-oxo-5H,6H,7H,8H,9H-[1,3,4]thiadiazolo[2,3-b]quinazolin-2-yl}piperidine-3-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L244-0143

Molecular Formula

C24H36N6O2S (C24 H36 N6 O2 S)

Compound Name

N-[3-(azepan-1-yl)propyl]-1-{5-oxo-5H,6H,7H,8H,9H-[1,3,4]thiadiazolo[2,3-b]quinazolin-2-yl}piperidine-3-carboxamide

IUPAC name

N-[3-(azepan-1-yl)propyl]-1-{5-oxo-5H6H7H8H9H-[134]thiadiazolo[23-b]quinazolin-2-yl}piperidine-3-carboxamide

SMILES

O=C(C(CCC1)CN1C(SC1=NC2=C3CCCC2)=NN1C3=O)NCCCN1CCCCCC1

InChI

InChI=1S/C24H36N6O2S/c31-21(25-12-8-15-28-13-5-1-2-6-14-28)18-9-7-16-29(17-18)24-27-30-22(32)19-10-3-4-11-20(19)26-23(30)33-24/h18H,1-17H2,(H,25,31)/t18-/m0/s1

InChI Key

KCNLXIKSEJMLFT-SFHVURJKSA-N

MDL Number (MFCD)

MFCD15120809

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

472.66

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

2.465

Distribution Coefficient, logD

-0.163

Water Solubility, LogSw

-2.58

Polar Surface Area

69.310

Acid Dissociation Constant (pKa)

15.00

Base Dissociation Constant (pKb)

10.03

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

75.00

L244-0143 in Drug Discovery

Included in Screening Libraries

Cysteine Proteases Inhibitors Library (7839 compounds)

GPCR Targeted Library (31838 compounds)

SmartTM Library (51161 compounds)

Akt-Targeted Library (14764 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Nervous system
  • Cardiovascular
  • Skin
  • Metabolic
  • Endocrine
  • Immune system
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Proteases
  • GPCR
  • Kinases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with L244-0143 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L244-0143?
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What is the minimum amount of L244-0143 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L244-0143
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L244-0143
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L244-0143 available by request