L251-1225 Screening compound: N-[(4-ethylphenyl)methyl]-2-{1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazole-5-carbonyl]piperidin-4-yl}propanamide

L251-1225 Screening compound: N-[(4-ethylphenyl)methyl]-2-{1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazole-5-carbonyl]piperidin-4-yl}propanamide
L251-1225 Screening compound: N-[(4-ethylphenyl)methyl]-2-{1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazole-5-carbonyl]piperidin-4-yl}propanamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L251-1225
N-[(4-ethylphenyl)methyl]-2-{1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazole-5-carbonyl]piperidin-4-yl}propanamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L251-1225

Molecular Formula

C28H32FN3O2S (C28 H32 FN3 O2 S)

Compound Name

N-[(4-ethylphenyl)methyl]-2-{1-[2-(4-fluorophenyl)-4-methyl-1,3-thiazole-5-carbonyl]piperidin-4-yl}propanamide

IUPAC name

N-[(4-ethylphenyl)methyl]-2-{1-[2-(4-fluorophenyl)-4-methyl-13-thiazole-5-carbonyl]piperidin-4-yl}propanamide

SMILES

CCc1ccc(CNC(C(C)C(CC2)CCN2C(c2c(C)nc(-c(cc3)ccc3F)s2)=O)=O)cc1

InChI

InChI=1S/C28H32FN3O2S/c1-4-20-5-7-21(8-6-20)17-30-26(33)18(2)22-13-15-32(16-14-22)28(34)25-19(3)31-27(35-25)23-9-11-24(29)12-10-23/h5-12,18,22H,4,13-17H2,1-3H3,(H,30,33)/t18-/m0/s1

InChI Key

TWHXNURTTOLUNT-SFHVURJKSA-N

MDL Number (MFCD)

MFCD27238227

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

493.65

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

5.346

Distribution Coefficient, logD

5.346

Water Solubility, LogSw

-5.27

Polar Surface Area

51.611

Acid Dissociation Constant (pKa)

12.56

Base Dissociation Constant (pKb)

0.82

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

39.30

L251-1225 in Drug Discovery

Included in Screening Libraries

MCL1 Targeted Library (12200 compounds)

Nonpeptide Peptidomimetics PPI Library (18997 compounds)

Protein-Protein Interaction Library (218420 compounds)

Protein Tyrosine Phosphatase Non-receptor Type (PTPN) Targeted Library (32556 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Cancer
  • Nervous system
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Endocrine
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics
Targets:
  • Phosphatases

References: we are preparing a list of scientific research reports with L251-1225 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L251-1225?
Check Price and Availability of L251-1225, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L251-1225 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L251-1225
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L251-1225
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L251-1225 available by request