L257-0231 Screening compound: 2,5-difluoro-N-{2-[1-(4-methylbenzoyl)piperidin-4-yl]ethyl}benzene-1-sulfonamide

L257-0231 Screening compound: 2,5-difluoro-N-{2-[1-(4-methylbenzoyl)piperidin-4-yl]ethyl}benzene-1-sulfonamide
L257-0231 Screening compound: 2,5-difluoro-N-{2-[1-(4-methylbenzoyl)piperidin-4-yl]ethyl}benzene-1-sulfonamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L257-0231
2,5-difluoro-N-{2-[1-(4-methylbenzoyl)piperidin-4-yl]ethyl}benzene-1-sulfonamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L257-0231

Molecular Formula

C21H24F2N2O3S (C21 H24 F2 N2 O3 S)

Compound Name

2,5-difluoro-N-{2-[1-(4-methylbenzoyl)piperidin-4-yl]ethyl}benzene-1-sulfonamide

IUPAC name

25-difluoro-N-{2-[1-(4-methylbenzoyl)piperidin-4-yl]ethyl}benzene-1-sulfonamide

SMILES

Cc(cc1)ccc1C(N1CCC(CCNS(c(cc(cc2)F)c2F)(=O)=O)CC1)=O

InChI

InChI=1S/C21H24F2N2O3S/c1-15-2-4-17(5-3-15)21(26)25-12-9-16(10-13-25)8-11-24-29(27,28)20-14-18(22)6-7-19(20)23/h2-7,14,16,24H,8-13H2,1H3

InChI Key

JRAITUPADOVRLT-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27238316

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

422.5

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

3.812

Distribution Coefficient, logD

3.812

Water Solubility, LogSw

-3.89

Polar Surface Area

58.486

Acid Dissociation Constant (pKa)

11.63

Base Dissociation Constant (pKb)

-2.57

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

38.10

L257-0231 in Drug Discovery

Included in Screening Libraries

PPI Helix Turn 3D-Mimetics Library (71298 compounds)

Protein-Protein Interaction Library (218420 compounds)

Alpha-Helix Mimetics Library (25899 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics
  • Mimetics
  • Cyclic compounds

References: we are preparing a list of scientific research reports with L257-0231 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L257-0231?
Check Price and Availability of L257-0231, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L257-0231 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L257-0231
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L257-0231
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L257-0231 available by request