L277-0286 Screening compound: 2-({4-[(3-bromophenyl)carbamoyl]piperazin-1-yl}methyl)-N,N,1-trimethyl-1H-1,3-benzodiazole-5-carboxamide

L277-0286 Screening compound: 2-({4-[(3-bromophenyl)carbamoyl]piperazin-1-yl}methyl)-N,N,1-trimethyl-1H-1,3-benzodiazole-5-carboxamide
L277-0286 Screening compound: 2-({4-[(3-bromophenyl)carbamoyl]piperazin-1-yl}methyl)-N,N,1-trimethyl-1H-1,3-benzodiazole-5-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L277-0286
2-({4-[(3-bromophenyl)carbamoyl]piperazin-1-yl}methyl)-N,N,1-trimethyl-1H-1,3-benzodiazole-5-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L277-0286

Molecular Formula

C23H27BrN6O2 (C23 H27 BrN6 O2)

Compound Name

2-({4-[(3-bromophenyl)carbamoyl]piperazin-1-yl}methyl)-N,N,1-trimethyl-1H-1,3-benzodiazole-5-carboxamide

IUPAC name

2-({4-[(3-bromophenyl)carbamoyl]piperazin-1-yl}methyl)-NN1-trimethyl-1H-13-benzodiazole-5-carboxamide

SMILES

CN(C)C(c(cc1)cc2c1n(C)c(CN(CC1)CCN1C(Nc1cccc(Br)c1)=O)n2)=O

InChI

InChI=1S/C23H27BrN6O2/c1-27(2)22(31)16-7-8-20-19(13-16)26-21(28(20)3)15-29-9-11-30(12-10-29)23(32)25-18-6-4-5-17(24)14-18/h4-8,13-14H,9-12,15H2,1-3H3,(H,25,32)

InChI Key

GBMMKAOGRHOEGC-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27239224

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

499.41

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

1.844

Distribution Coefficient, logD

1.399

Water Solubility, LogSw

-2.54

Polar Surface Area

57.235

Acid Dissociation Constant (pKa)

12.15

Base Dissociation Constant (pKb)

7.65

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

34.80

L277-0286 in Drug Discovery

Included in Screening Libraries

PI3K-Targeted Library (17255 compounds)

Epigenetics Focused Set (26518 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with L277-0286 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L277-0286?
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What is the minimum amount of L277-0286 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L277-0286
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L277-0286
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L277-0286 available by request