L281-0143 Screening compound: N-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-3,4-dimethoxybenzamide

L281-0143 Screening compound: N-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-3,4-dimethoxybenzamide
L281-0143 Screening compound: N-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-3,4-dimethoxybenzamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L281-0143
N-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-3,4-dimethoxybenzamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L281-0143

Molecular Formula

C23H23N5O3S (C23 H23 N5 O3 S)

Compound Name

N-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-3,4-dimethoxybenzamide

IUPAC name

N-[4-({6-ethyl-5-methyl-[124]triazolo[15-a]pyrimidin-7-yl}sulfanyl)phenyl]-34-dimethoxybenzamide

SMILES

CCc(c(C)nc1ncnn11)c1Sc(cc1)ccc1NC(c(cc1)cc(OC)c1OC)=O

InChI

InChI=1S/C23H23N5O3S/c1-5-18-14(2)26-23-24-13-25-28(23)22(18)32-17-9-7-16(8-10-17)27-21(29)15-6-11-19(30-3)20(12-15)31-4/h6-13H,5H2,1-4H3,(H,27,29)

InChI Key

JGKIFAJYMZLSER-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15122550

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

449.53

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.987

Distribution Coefficient, logD

3.987

Water Solubility, LogSw

-4.22

Polar Surface Area

70.648

Acid Dissociation Constant (pKa)

11.96

Base Dissociation Constant (pKb)

3.71

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

21.70

L281-0143 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
Targets:
  • Proteases

References: we are preparing a list of scientific research reports with L281-0143 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L281-0143?
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What is the minimum amount of L281-0143 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L281-0143
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L281-0143
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L281-0143 available by request