L281-0148 Screening compound: 2-(4-chlorophenoxy)-N-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]acetamide

L281-0148 Screening compound: 2-(4-chlorophenoxy)-N-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]acetamide
L281-0148 Screening compound: 2-(4-chlorophenoxy)-N-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L281-0148
2-(4-chlorophenoxy)-N-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L281-0148

Molecular Formula

C22H20ClN5O2S (C22 H20 ClN5 O2 S)

Compound Name

2-(4-chlorophenoxy)-N-[4-({6-ethyl-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]acetamide

IUPAC name

2-(4-chlorophenoxy)-N-[4-({6-ethyl-5-methyl-[124]triazolo[15-a]pyrimidin-7-yl}sulfanyl)phenyl]acetamide

SMILES

CCc(c(C)nc1ncnn11)c1Sc(cc1)ccc1NC(COc(cc1)ccc1Cl)=O

InChI

InChI=1S/C22H20ClN5O2S/c1-3-19-14(2)26-22-24-13-25-28(22)21(19)31-18-10-6-16(7-11-18)27-20(29)12-30-17-8-4-15(23)5-9-17/h4-11,13H,3,12H2,1-2H3,(H,27,29)

InChI Key

CYUMSHGJOQSCET-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15122554

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

453.95

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.992

Distribution Coefficient, logD

4.992

Water Solubility, LogSw

-4.95

Polar Surface Area

62.673

Acid Dissociation Constant (pKa)

12.51

Base Dissociation Constant (pKb)

3.71

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

18.20

L281-0148 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

C-Met Library (15277 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Endocrine
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
Targets:
  • Kinases
  • Proteases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with L281-0148 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L281-0148?
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What is the minimum amount of L281-0148 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L281-0148
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L281-0148
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L281-0148 available by request