L281-0418 Screening compound: 3-(2-chlorophenyl)-N-[4-({5-ethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-5-methyl-1,2-oxazole-4-carboxamide

L281-0418 Screening compound: 3-(2-chlorophenyl)-N-[4-({5-ethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-5-methyl-1,2-oxazole-4-carboxamide
L281-0418 Screening compound: 3-(2-chlorophenyl)-N-[4-({5-ethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-5-methyl-1,2-oxazole-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L281-0418
3-(2-chlorophenyl)-N-[4-({5-ethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-5-methyl-1,2-oxazole-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L281-0418

Molecular Formula

C24H19ClN6O2S (C24 H19 ClN6 O2 S)

Compound Name

3-(2-chlorophenyl)-N-[4-({5-ethyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}sulfanyl)phenyl]-5-methyl-1,2-oxazole-4-carboxamide

IUPAC name

3-(2-chlorophenyl)-N-[4-({5-ethyl-[124]triazolo[15-a]pyrimidin-7-yl}sulfanyl)phenyl]-5-methyl-12-oxazole-4-carboxamide

SMILES

CCc1nc2ncnn2c(Sc(cc2)ccc2NC(c2c(C)onc2-c(cccc2)c2Cl)=O)c1

InChI

InChI=1S/C24H19ClN6O2S/c1-3-15-12-20(31-24(29-15)26-13-27-31)34-17-10-8-16(9-11-17)28-23(32)21-14(2)33-30-22(21)18-6-4-5-7-19(18)25/h4-13H,3H2,1-2H3,(H,28,32)

InChI Key

QGQGLLALEHSAKI-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15122597

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

490.97

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

4.957

Distribution Coefficient, logD

4.957

Water Solubility, LogSw

-5.06

Polar Surface Area

77.489

Acid Dissociation Constant (pKa)

10.90

Base Dissociation Constant (pKb)

3.47

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

12.50

L281-0418 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

C-Met Library (15277 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

New Agro Library (44492 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Endocrine
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
Targets:
  • Kinases
  • Proteases
Mechanism of action:
  • Receptor's ligands
Agro:
  • Agro

References: we are preparing a list of scientific research reports with L281-0418 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L281-0418?
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What is the minimum amount of L281-0418 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L281-0418
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L281-0418
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L281-0418 available by request