L287-2499 Screening compound: (2E)-1-(4-{[4-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)thiophen-2-yl]sulfonyl}piperazin-1-yl)-3-(furan-2-yl)prop-2-en-1-one

L287-2499 Screening compound: (2E)-1-(4-{[4-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)thiophen-2-yl]sulfonyl}piperazin-1-yl)-3-(furan-2-yl)prop-2-en-1-one
L287-2499 Screening compound: (2E)-1-(4-{[4-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)thiophen-2-yl]sulfonyl}piperazin-1-yl)-3-(furan-2-yl)prop-2-en-1-one alternative view

Chemical Structure Depiction of ChemDiv screening compound L287-2499
(2E)-1-(4-{[4-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)thiophen-2-yl]sulfonyl}piperazin-1-yl)-3-(furan-2-yl)prop-2-en-1-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L287-2499

Molecular Formula

C21H22N4O5S2 (C21 H22 N4 O5 S2)

Compound Name

(2E)-1-(4-{[4-(5-cyclobutyl-1,2,4-oxadiazol-3-yl)thiophen-2-yl]sulfonyl}piperazin-1-yl)-3-(furan-2-yl)prop-2-en-1-one

IUPAC name

(2E)-1-(4-{[4-(5-cyclobutyl-124-oxadiazol-3-yl)thiophen-2-yl]sulfonyl}piperazin-1-yl)-3-(furan-2-yl)prop-2-en-1-one

SMILES

O=C(/C=C/c1ccco1)N(CC1)CCN1S(c1cc(-c2noc(C3CCC3)n2)cs1)(=O)=O

InChI

InChI=1S/C21H22N4O5S2/c26-18(7-6-17-5-2-12-29-17)24-8-10-25(11-9-24)32(27,28)19-13-16(14-31-19)20-22-21(30-23-20)15-3-1-4-15/h2,5-7,12-15H,1,3-4,8-11H2

InChI Key

BYIJDUAEVRESSN-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27240997

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

474.56

Hydrogen Bond Acceptors Count

11.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

3.016

Distribution Coefficient, logD

3.016

Water Solubility, LogSw

-3.28

Polar Surface Area

88.574

Acid Dissociation Constant (pKa)

26.82

Base Dissociation Constant (pKb)

-0.07

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

38.10

L287-2499 in Drug Discovery

Included in Screening Libraries

Eccentric PPI Library (11937 compounds)

KRAS-Targeted Library (16000 compounds)

Protein-Protein Interaction Library (218420 compounds)

?ysteine Targeted Covalent Library (39471 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Cyclic compounds
Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with L287-2499 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L287-2499?
Check Price and Availability of L287-2499, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L287-2499 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L287-2499
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L287-2499
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L287-2499 available by request