L291-0365 Screening compound: 4-chloro-N-{1-[(2E)-3-(4-methylphenyl)prop-2-enoyl]piperidin-4-yl}benzene-1-sulfonamide

L291-0365 Screening compound: 4-chloro-N-{1-[(2E)-3-(4-methylphenyl)prop-2-enoyl]piperidin-4-yl}benzene-1-sulfonamide
L291-0365 Screening compound: 4-chloro-N-{1-[(2E)-3-(4-methylphenyl)prop-2-enoyl]piperidin-4-yl}benzene-1-sulfonamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L291-0365
4-chloro-N-{1-[(2E)-3-(4-methylphenyl)prop-2-enoyl]piperidin-4-yl}benzene-1-sulfonamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L291-0365

Molecular Formula

C21H23ClN2O3S (C21 H23 ClN2 O3 S)

Compound Name

4-chloro-N-{1-[(2E)-3-(4-methylphenyl)prop-2-enoyl]piperidin-4-yl}benzene-1-sulfonamide

IUPAC name

4-chloro-N-{1-[(2E)-3-(4-methylphenyl)prop-2-enoyl]piperidin-4-yl}benzene-1-sulfonamide

SMILES

Cc1ccc(/C=C/C(N(CC2)CCC2NS(c(cc2)ccc2Cl)(=O)=O)=O)cc1

InChI

InChI=1S/C21H23ClN2O3S/c1-16-2-4-17(5-3-16)6-11-21(25)24-14-12-19(13-15-24)23-28(26,27)20-9-7-18(22)8-10-20/h2-11,19,23H,12-15H2,1H3

InChI Key

VAVNVDAGGGDUEI-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27241419

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

418.94

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

4.306

Distribution Coefficient, logD

4.306

Water Solubility, LogSw

-4.78

Polar Surface Area

57.864

Acid Dissociation Constant (pKa)

11.28

Base Dissociation Constant (pKb)

2.49

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

28.60

L291-0365 in Drug Discovery

Included in Screening Libraries

Covalent Inhibitors Library (7986 compounds)

?ysteine Targeted Covalent Library (39471 compounds)

Included in 1.7M Stock Database

Structure:
  • Cyclic compounds
  • 3D
  • Fragments

References: we are preparing a list of scientific research reports with L291-0365 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L291-0365?
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What is the minimum amount of L291-0365 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L291-0365
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L291-0365
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L291-0365 available by request