L291-0659 Screening compound: 4-methoxy-N-{1-[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]piperidin-4-yl}benzene-1-sulfonamide

L291-0659 Screening compound: 4-methoxy-N-{1-[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]piperidin-4-yl}benzene-1-sulfonamide
L291-0659 Screening compound: 4-methoxy-N-{1-[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]piperidin-4-yl}benzene-1-sulfonamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L291-0659
4-methoxy-N-{1-[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]piperidin-4-yl}benzene-1-sulfonamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L291-0659

Molecular Formula

C22H26N2O5S (C22 H26 N2 O5 S)

Compound Name

4-methoxy-N-{1-[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]piperidin-4-yl}benzene-1-sulfonamide

IUPAC name

4-methoxy-N-{1-[(2E)-3-(4-methoxyphenyl)prop-2-enoyl]piperidin-4-yl}benzene-1-sulfonamide

SMILES

COc1ccc(/C=C/C(N(CC2)CCC2NS(c(cc2)ccc2OC)(=O)=O)=O)cc1

InChI

InChI=1S/C22H26N2O5S/c1-28-19-6-3-17(4-7-19)5-12-22(25)24-15-13-18(14-16-24)23-30(26,27)21-10-8-20(29-2)9-11-21/h3-12,18,23H,13-16H2,1-2H3

InChI Key

LTGZZLDRZFADHJ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27241497

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

430.52

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.253

Distribution Coefficient, logD

3.253

Water Solubility, LogSw

-3.64

Polar Surface Area

72.952

Acid Dissociation Constant (pKa)

11.71

Base Dissociation Constant (pKb)

2.49

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

31.80

L291-0659 in Drug Discovery

Included in Screening Libraries

KRAS-Targeted Library (16000 compounds)

Covalent Inhibitors Library (7986 compounds)

?ysteine Targeted Covalent Library (39471 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases
Structure:
  • Cyclic compounds
  • 3D
  • Fragments

References: we are preparing a list of scientific research reports with L291-0659 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L291-0659?
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What is the minimum amount of L291-0659 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L291-0659
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L291-0659
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L291-0659 available by request