L299-0462 Screening compound: 2-methyl-5-{2-methyl-5,8-dioxo-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,3]diazepin-3-yl}-N-[(4-methylphenyl)methyl]benzene-1-sulfonamide

L299-0462 Screening compound: 2-methyl-5-{2-methyl-5,8-dioxo-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,3]diazepin-3-yl}-N-[(4-methylphenyl)methyl]benzene-1-sulfonamide
L299-0462 Screening compound: 2-methyl-5-{2-methyl-5,8-dioxo-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,3]diazepin-3-yl}-N-[(4-methylphenyl)methyl]benzene-1-sulfonamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L299-0462
2-methyl-5-{2-methyl-5,8-dioxo-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,3]diazepin-3-yl}-N-[(4-methylphenyl)methyl]benzene-1-sulfonamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L299-0462

Molecular Formula

C23H24N4O4S (C23 H24 N4 O4 S)

Compound Name

2-methyl-5-{2-methyl-5,8-dioxo-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,3]diazepin-3-yl}-N-[(4-methylphenyl)methyl]benzene-1-sulfonamide

IUPAC name

2-methyl-5-{2-methyl-58-dioxo-4H5H6H7H8H-pyrazolo[15-a][13]diazepin-3-yl}-N-[(4-methylphenyl)methyl]benzene-1-sulfonamide

SMILES

Cc(c(-c1cc(S(NCc2ccc(C)cc2)(=O)=O)c(C)cc1)c1NC(CC2)=O)nn1C2=O

InChI

InChI=1S/C23H24N4O4S/c1-14-4-7-17(8-5-14)13-24-32(30,31)19-12-18(9-6-15(19)2)22-16(3)26-27-21(29)11-10-20(28)25-23(22)27/h4-9,12,24H,10-11,13H2,1-3H3,(H,25,28)

InChI Key

DCDVEXRYYFUABK-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27242308

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

452.53

Hydrogen Bond Acceptors Count

10.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

2.282

Distribution Coefficient, logD

1.996

Water Solubility, LogSw

-2.97

Polar Surface Area

94.171

Acid Dissociation Constant (pKa)

7.43

Base Dissociation Constant (pKb)

-2.44

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

26.10

L299-0462 in Drug Discovery

Included in Screening Libraries

3D-Pharmacophore Based Diversity Library (49813 compounds)

BRD4 Targeted Library (4534 compounds)

Protein-Protein Interaction Library (218420 compounds)

SmartTM Library (51161 compounds)

Recognition Elements PPI Library (24135 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Hemic and lymphatic
  • Cardiovascular
  • Metabolic
Targets:
  • Others
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with L299-0462 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L299-0462?
Check Price and Availability of L299-0462, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L299-0462 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L299-0462
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L299-0462
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L299-0462 available by request