L299-2444 Screening compound: 2-ethyl-3-[4-methyl-3-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)phenyl]-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,3]diazepine-5,8-dione

L299-2444 Screening compound: 2-ethyl-3-[4-methyl-3-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)phenyl]-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,3]diazepine-5,8-dione
L299-2444 Screening compound: 2-ethyl-3-[4-methyl-3-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)phenyl]-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,3]diazepine-5,8-dione alternative view

Chemical Structure Depiction of ChemDiv screening compound L299-2444
2-ethyl-3-[4-methyl-3-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)phenyl]-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,3]diazepine-5,8-dione

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L299-2444

Molecular Formula

C25H26N4O4S (C25 H26 N4 O4 S)

Compound Name

2-ethyl-3-[4-methyl-3-(1,2,3,4-tetrahydroisoquinoline-2-sulfonyl)phenyl]-4H,5H,6H,7H,8H-pyrazolo[1,5-a][1,3]diazepine-5,8-dione

IUPAC name

2-ethyl-3-[4-methyl-3-(1234-tetrahydroisoquinoline-2-sulfonyl)phenyl]-4H5H6H7H8H-pyrazolo[15-a][13]diazepine-58-dione

SMILES

CCc(c(-c1cc(S(N(CC2)Cc3c2cccc3)(=O)=O)c(C)cc1)c1NC(CC2)=O)nn1C2=O

InChI

InChI=1S/C25H26N4O4S/c1-3-20-24(25-26-22(30)10-11-23(31)29(25)27-20)18-9-8-16(2)21(14-18)34(32,33)28-13-12-17-6-4-5-7-19(17)15-28/h4-9,14H,3,10-13,15H2,1-2H3,(H,26,30)

InChI Key

ZWSKGATUWHAYER-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27242453

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

478.57

Hydrogen Bond Acceptors Count

10.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.034

Distribution Coefficient, logD

2.759

Water Solubility, LogSw

-3.40

Polar Surface Area

84.475

Acid Dissociation Constant (pKa)

7.45

Base Dissociation Constant (pKb)

-2.20

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

32.00

L299-2444 in Drug Discovery

Included in Screening Libraries

Allosteric Kinases Inhibitors Library (23117 compounds)

KRAS-Targeted Library (16000 compounds)

Protein-Protein Interaction Library (218420 compounds)

SmartTM Library (51161 compounds)

Recognition Elements PPI Library (24135 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Female
  • Congenital
  • Skin
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases
  • Kinases
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with L299-2444 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L299-2444?
Check Price and Availability of L299-2444, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L299-2444 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L299-2444
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L299-2444
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L299-2444 available by request