L327-8261 Screening compound: 4-[5-(cyclopentylamino)-6-(4-ethylphenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-N-(2-methoxyethyl)piperazine-1-carboxamide

L327-8261 Screening compound: 4-[5-(cyclopentylamino)-6-(4-ethylphenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-N-(2-methoxyethyl)piperazine-1-carboxamide
L327-8261 Screening compound: 4-[5-(cyclopentylamino)-6-(4-ethylphenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-N-(2-methoxyethyl)piperazine-1-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L327-8261
4-[5-(cyclopentylamino)-6-(4-ethylphenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-N-(2-methoxyethyl)piperazine-1-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L327-8261

Molecular Formula

C25H35N7O2S (C25 H35 N7 O2 S)

Compound Name

4-[5-(cyclopentylamino)-6-(4-ethylphenyl)imidazo[2,1-b][1,3,4]thiadiazol-2-yl]-N-(2-methoxyethyl)piperazine-1-carboxamide

IUPAC name

4-[5-(cyclopentylamino)-6-(4-ethylphenyl)imidazo[21-b][134]thiadiazol-2-yl]-N-(2-methoxyethyl)piperazine-1-carboxamide

SMILES

CCc(cc1)ccc1-c1c(NC2CCCC2)n2nc(N(CC3)CCN3C(NCCOC)=O)sc2n1

InChI

InChI=1S/C25H35N7O2S/c1-3-18-8-10-19(11-9-18)21-22(27-20-6-4-5-7-20)32-24(28-21)35-25(29-32)31-15-13-30(14-16-31)23(33)26-12-17-34-2/h8-11,20,27H,3-7,12-17H2,1-2H3,(H,26,33)

InChI Key

MDVCEDAXKPHMKY-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27245945

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

497.66

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

10.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

4.718

Distribution Coefficient, logD

4.716

Water Solubility, LogSw

-4.38

Polar Surface Area

69.830

Acid Dissociation Constant (pKa)

15.96

Base Dissociation Constant (pKb)

4.91

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

56.00

L327-8261 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with L327-8261 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L327-8261?
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What is the minimum amount of L327-8261 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L327-8261
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L327-8261
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L327-8261 available by request