L328-0353 Screening compound: 1,3-dimethyl-6-{3-[4-(pyrimidin-2-yl)piperazine-1-carbonyl]piperidin-1-yl}-1,2,3,4-tetrahydropyrimidine-2,4-dione

L328-0353 Screening compound: 1,3-dimethyl-6-{3-[4-(pyrimidin-2-yl)piperazine-1-carbonyl]piperidin-1-yl}-1,2,3,4-tetrahydropyrimidine-2,4-dione
L328-0353 Screening compound: 1,3-dimethyl-6-{3-[4-(pyrimidin-2-yl)piperazine-1-carbonyl]piperidin-1-yl}-1,2,3,4-tetrahydropyrimidine-2,4-dione alternative view

Chemical Structure Depiction of ChemDiv screening compound L328-0353
1,3-dimethyl-6-{3-[4-(pyrimidin-2-yl)piperazine-1-carbonyl]piperidin-1-yl}-1,2,3,4-tetrahydropyrimidine-2,4-dione

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L328-0353

Molecular Formula

C20H27N7O3 (C20 H27 N7 O3)

Compound Name

1,3-dimethyl-6-{3-[4-(pyrimidin-2-yl)piperazine-1-carbonyl]piperidin-1-yl}-1,2,3,4-tetrahydropyrimidine-2,4-dione

IUPAC name

13-dimethyl-6-{3-[4-(pyrimidin-2-yl)piperazine-1-carbonyl]piperidin-1-yl}-1234-tetrahydropyrimidine-24-dione

SMILES

CN(C(C=C(N1C)N(CCC2)CC2C(N(CC2)CCN2c2ncccn2)=O)=O)C1=O

InChI

InChI=1S/C20H27N7O3/c1-23-16(13-17(28)24(2)20(23)30)27-8-3-5-15(14-27)18(29)25-9-11-26(12-10-25)19-21-6-4-7-22-19/h4,6-7,13,15H,3,5,8-12,14H2,1-2H3/t15-/m0/s1

InChI Key

FZKJBHGQMMCLPD-HNNXBMFYSA-N

MDL Number (MFCD)

MFCD27246152

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

413.48

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

10

Partition Coefficient, logP

0.801

Distribution Coefficient, logD

0.801

Water Solubility, LogSw

-0.73

Polar Surface Area

73.929

Acid Dissociation Constant (pKa)

21.15

Base Dissociation Constant (pKb)

2.67

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

55.00

L328-0353 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Protein-Protein Interaction Library (218420 compounds)

SmartTM Library (51161 compounds)

Targeted Diversity Library (40567 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Included in 1.7M Stock Database

Mechanism of action:
  • PPI modulators
Structure:
  • Cyclic compounds

References: we are preparing a list of scientific research reports with L328-0353 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L328-0353?
Check Price and Availability of L328-0353, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L328-0353 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L328-0353
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L328-0353
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L328-0353 available by request