L337-0285 Screening compound: 1-(3-chlorophenyl)-3-{5-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1,3,4-thiadiazol-2-yl}urea

L337-0285 Screening compound: 1-(3-chlorophenyl)-3-{5-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1,3,4-thiadiazol-2-yl}urea
L337-0285 Screening compound: 1-(3-chlorophenyl)-3-{5-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1,3,4-thiadiazol-2-yl}urea alternative view

Chemical Structure Depiction of ChemDiv screening compound L337-0285
1-(3-chlorophenyl)-3-{5-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1,3,4-thiadiazol-2-yl}urea

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L337-0285

Molecular Formula

C15H16ClN5O2S (C15 H16 ClN5 O2 S)

Compound Name

1-(3-chlorophenyl)-3-{5-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1,3,4-thiadiazol-2-yl}urea

IUPAC name

1-(3-chlorophenyl)-3-{5-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-134-thiadiazol-2-yl}urea

SMILES

O=C(Cc1nnc(NC(Nc2cccc(Cl)c2)=O)s1)N1CCCC1

InChI

InChI=1S/C15H16ClN5O2S/c16-10-4-3-5-11(8-10)17-14(23)18-15-20-19-12(24-15)9-13(22)21-6-1-2-7-21/h3-5,8H,1-2,6-7,9H2,(H2,17,18,20,23)

InChI Key

LMFKOASHPJUNNZ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27247085

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

365.84

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.403

Distribution Coefficient, logD

3.383

Water Solubility, LogSw

-3.79

Polar Surface Area

73.069

Acid Dissociation Constant (pKa)

8.72

Base Dissociation Constant (pKb)

-1.05

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

33.30

L337-0285 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Human Kinases Annotated Library (2415 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Selective Target Activity Profiling Library (14702 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with L337-0285 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L337-0285?
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What is the minimum amount of L337-0285 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L337-0285
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L337-0285
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L337-0285 available by request