L337-0493 Screening compound: 3-{5-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-1,3,4-thiadiazol-2-yl}-1-(2-methoxyphenyl)urea

L337-0493 Screening compound: 3-{5-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-1,3,4-thiadiazol-2-yl}-1-(2-methoxyphenyl)urea
L337-0493 Screening compound: 3-{5-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-1,3,4-thiadiazol-2-yl}-1-(2-methoxyphenyl)urea alternative view

Chemical Structure Depiction of ChemDiv screening compound L337-0493
3-{5-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-1,3,4-thiadiazol-2-yl}-1-(2-methoxyphenyl)urea

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L337-0493

Molecular Formula

C20H19N5O3S (C20 H19 N5 O3 S)

Compound Name

3-{5-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]-1,3,4-thiadiazol-2-yl}-1-(2-methoxyphenyl)urea

IUPAC name

3-{5-[2-(23-dihydro-1H-indol-1-yl)-2-oxoethyl]-134-thiadiazol-2-yl}-1-(2-methoxyphenyl)urea

SMILES

COc(cccc1)c1NC(Nc1nnc(CC(N(CC2)c3c2cccc3)=O)s1)=O

InChI

InChI=1S/C20H19N5O3S/c1-28-16-9-5-3-7-14(16)21-19(27)22-20-24-23-17(29-20)12-18(26)25-11-10-13-6-2-4-8-15(13)25/h2-9H,10-12H2,1H3,(H2,21,22,24,27)

InChI Key

UNVXOZXGKBFWOH-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27247093

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

409.47

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.663

Distribution Coefficient, logD

3.663

Water Solubility, LogSw

-3.93

Polar Surface Area

78.666

Acid Dissociation Constant (pKa)

10.27

Base Dissociation Constant (pKb)

0.44

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

20.00

L337-0493 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Targeted Diversity Library (40567 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with L337-0493 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L337-0493?
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What is the minimum amount of L337-0493 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L337-0493
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L337-0493
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L337-0493 available by request