L346-0035 Screening compound: N-butyl-5-{[(4-chlorophenyl)sulfonyl]amino}-2-piperazinonicotinamide

L346-0035 Screening compound: N-butyl-5-{[(4-chlorophenyl)sulfonyl]amino}-2-piperazinonicotinamide
L346-0035 Screening compound: N-butyl-5-{[(4-chlorophenyl)sulfonyl]amino}-2-piperazinonicotinamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L346-0035
N-butyl-5-{[(4-chlorophenyl)sulfonyl]amino}-2-piperazinonicotinamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L346-0035

Molecular Formula

C20H26ClN5O3S (C20 H26 ClN5 O3 S)

Compound Name

N-butyl-5-{[(4-chlorophenyl)sulfonyl]amino}-2-piperazinonicotinamide

IUPAC name

N-butyl-5-(4-chlorobenzenesulfonamido)-2-(piperazin-1-yl)pyridine-3-carboxamide

SMILES

CCCCNC(c1cc(NS(c(cc2)ccc2Cl)(=O)=O)cnc1N1CCNCC1)=O

InChI

InChI=1S/C20H26ClN5O3S/c1-2-3-8-23-20(27)18-13-16(14-24-19(18)26-11-9-22-10-12-26)25-30(28,29)17-6-4-15(21)5-7-17/h4-7,13-14,22,25H,2-3,8-12H2,1H3,(H,23,27)

InChI Key

VMBYGOMBUBSWHR-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27247275

Chemical and Physical Properties

Saltdata

CF3COOH

Molecular Weight

451.98

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

3.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.308

Distribution Coefficient, logD

1.830

Water Solubility, LogSw

-3.74

Polar Surface Area

89.898

Acid Dissociation Constant (pKa)

7.42

Base Dissociation Constant (pKb)

8.86

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

40.00

L346-0035 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

PI3K-Targeted Library (17255 compounds)

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

Epigenetics Focused Set (26518 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with L346-0035 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L346-0035?
Check Price and Availability of L346-0035, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L346-0035 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L346-0035
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L346-0035
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L346-0035 available by request