L369-0511 Screening compound: 3-{[5-(3-fluorophenyl)pyrimidin-2-yl]amino}-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzamide

L369-0511 Screening compound: 3-{[5-(3-fluorophenyl)pyrimidin-2-yl]amino}-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzamide
L369-0511 Screening compound: 3-{[5-(3-fluorophenyl)pyrimidin-2-yl]amino}-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L369-0511
3-{[5-(3-fluorophenyl)pyrimidin-2-yl]amino}-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L369-0511

Molecular Formula

C27H23FN4O (C27 H23 FN4 O)

Compound Name

3-{[5-(3-fluorophenyl)pyrimidin-2-yl]amino}-N-(1,2,3,4-tetrahydronaphthalen-1-yl)benzamide

IUPAC name

3-{[5-(3-fluorophenyl)pyrimidin-2-yl]amino}-N-(1234-tetrahydronaphthalen-1-yl)benzamide

SMILES

O=C(c1cccc(Nc(nc2)ncc2-c2cccc(F)c2)c1)NC(CCC1)c2c1cccc2

InChI

InChI=1S/C27H23FN4O/c28-22-10-3-8-19(14-22)21-16-29-27(30-17-21)31-23-11-4-9-20(15-23)26(33)32-25-13-5-7-18-6-1-2-12-24(18)25/h1-4,6,8-12,14-17,25H,5,7,13H2,(H,32,33)(H,29,30,31)/t25-/m0/s1

InChI Key

QCKLSAYFZCCDCF-VWLOTQADSA-N

MDL Number (MFCD)

MFCD27248542

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

438.5

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

5.767

Distribution Coefficient, logD

5.767

Water Solubility, LogSw

-5.73

Polar Surface Area

53.885

Acid Dissociation Constant (pKa)

10.88

Base Dissociation Constant (pKb)

1.89

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

14.80

L369-0511 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

C-Met Library (15277 compounds)

Targeted Diversity Library (40567 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Endocrine
Targets:
  • Kinases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with L369-0511 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L369-0511?
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What is the minimum amount of L369-0511 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L369-0511
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L369-0511
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L369-0511 available by request