L372-0659 Screening compound: N-[4-(diethylamino)-2-methylphenyl]-2,5-dioxo-1-[4-(propan-2-yl)phenyl]-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide

L372-0659 Screening compound: N-[4-(diethylamino)-2-methylphenyl]-2,5-dioxo-1-[4-(propan-2-yl)phenyl]-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide
L372-0659 Screening compound: N-[4-(diethylamino)-2-methylphenyl]-2,5-dioxo-1-[4-(propan-2-yl)phenyl]-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L372-0659
N-[4-(diethylamino)-2-methylphenyl]-2,5-dioxo-1-[4-(propan-2-yl)phenyl]-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L372-0659

Molecular Formula

C30H35N3O3 (C30 H35 N3 O3)

Compound Name

N-[4-(diethylamino)-2-methylphenyl]-2,5-dioxo-1-[4-(propan-2-yl)phenyl]-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide

IUPAC name

N-[4-(diethylamino)-2-methylphenyl]-25-dioxo-1-[4-(propan-2-yl)phenyl]-125678-hexahydroquinoline-3-carboxamide

SMILES

CCN(CC)c(cc1)cc(C)c1NC(C1=CC(C(CCC2)=O)=C2N(c2ccc(C(C)C)cc2)C1=O)=O

InChI

InChI=1S/C30H35N3O3/c1-6-32(7-2)23-15-16-26(20(5)17-23)31-29(35)25-18-24-27(9-8-10-28(24)34)33(30(25)36)22-13-11-21(12-14-22)19(3)4/h11-19H,6-10H2,1-5H3,(H,31,35)

InChI Key

XSIHVYRSRWMMKN-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15125643

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

485.63

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

5.202

Distribution Coefficient, logD

4.978

Water Solubility, LogSw

-5.01

Polar Surface Area

53.709

Acid Dissociation Constant (pKa)

8.86

Base Dissociation Constant (pKb)

9.85

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

36.70

L372-0659 in Drug Discovery

Included in Screening Libraries

Anti-Inflammatory Library (24602 compounds)

Anticancer Library (62698 compounds)

C-Met Library (15277 compounds)

Regenerative Medicine Focused Library (23016 compounds)

Protein Tyrosine Phosphatase Non-receptor Type (PTPN) Targeted Library (32556 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Immune system
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Endocrine
  • Musculoskeletal
  • Digestive system
  • Hemic and lymphatic
  • Cardiovascular
  • Skin
  • wounds
  • Cancer
  • Nervous system
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Endocrine
Targets:
  • Kinases
  • Phosphatases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with L372-0659 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L372-0659?
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What is the minimum amount of L372-0659 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L372-0659
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L372-0659
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L372-0659 available by request