L418-0111 Screening compound: 5-[4-(morpholine-4-carbonyl)phenyl]-N-[2-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indole-1-carboxamide

L418-0111 Screening compound: 5-[4-(morpholine-4-carbonyl)phenyl]-N-[2-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indole-1-carboxamide
L418-0111 Screening compound: 5-[4-(morpholine-4-carbonyl)phenyl]-N-[2-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indole-1-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L418-0111
5-[4-(morpholine-4-carbonyl)phenyl]-N-[2-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indole-1-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L418-0111

Molecular Formula

C27H24F3N3O3 (C27 H24 F3 N3 O3)

Compound Name

5-[4-(morpholine-4-carbonyl)phenyl]-N-[2-(trifluoromethyl)phenyl]-2,3-dihydro-1H-indole-1-carboxamide

IUPAC name

5-[4-(morpholine-4-carbonyl)phenyl]-N-[2-(trifluoromethyl)phenyl]-23-dihydro-1H-indole-1-carboxamide

SMILES

O=C(c(cc1)ccc1-c(cc1)cc(CC2)c1N2C(Nc1c(C(F)(F)F)cccc1)=O)N1CCOCC1

InChI

InChI=1S/C27H24F3N3O3/c28-27(29,30)22-3-1-2-4-23(22)31-26(35)33-12-11-21-17-20(9-10-24(21)33)18-5-7-19(8-6-18)25(34)32-13-15-36-16-14-32/h1-10,17H,11-16H2,(H,31,35)

InChI Key

UABMRPFUNDQOFZ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15126825

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

495.5

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

5.019

Distribution Coefficient, logD

5.019

Water Solubility, LogSw

-4.80

Polar Surface Area

48.326

Acid Dissociation Constant (pKa)

12.78

Base Dissociation Constant (pKb)

-2.13

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

25.90

L418-0111 in Drug Discovery

Included in Screening Libraries

Bromodomain Modulators Library (5801 compounds)

Lipid Metabolism Library (9174 compounds)

PI3K-Targeted Library (17255 compounds)

MDM2-p53 interaction inhibitors Library (21687 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cardiovascular
  • Metabolic
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Cancer
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with L418-0111 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L418-0111?
Check Price and Availability of L418-0111, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L418-0111 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L418-0111
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L418-0111
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L418-0111 available by request