L438-0269 Screening compound: methyl 3-({[8-fluoro-2-(morpholin-4-yl)quinolin-6-yl]carbamoyl}amino)benzoate

L438-0269 Screening compound: methyl 3-({[8-fluoro-2-(morpholin-4-yl)quinolin-6-yl]carbamoyl}amino)benzoate
L438-0269 Screening compound: methyl 3-({[8-fluoro-2-(morpholin-4-yl)quinolin-6-yl]carbamoyl}amino)benzoate alternative view

Chemical Structure Depiction of ChemDiv screening compound L438-0269
methyl 3-({[8-fluoro-2-(morpholin-4-yl)quinolin-6-yl]carbamoyl}amino)benzoate

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L438-0269

Molecular Formula

C22H21FN4O4 (C22 H21 FN4 O4)

Compound Name

methyl 3-({[8-fluoro-2-(morpholin-4-yl)quinolin-6-yl]carbamoyl}amino)benzoate

IUPAC name

methyl 3-({[8-fluoro-2-(morpholin-4-yl)quinolin-6-yl]carbamoyl}amino)benzoate

SMILES

COC(c1cccc(NC(Nc2cc3ccc(N4CCOCC4)nc3c(F)c2)=O)c1)=O

InChI

InChI=1S/C22H21FN4O4/c1-30-21(28)15-3-2-4-16(12-15)24-22(29)25-17-11-14-5-6-19(26-20(14)18(23)13-17)27-7-9-31-10-8-27/h2-6,11-13H,7-10H2,1H3,(H2,24,25,29)

InChI Key

WESFZGDOADHIEK-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27252768

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

424.43

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

4.839

Distribution Coefficient, logD

4.839

Water Solubility, LogSw

-4.95

Polar Surface Area

73.641

Acid Dissociation Constant (pKa)

11.74

Base Dissociation Constant (pKb)

3.94

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

22.73

L438-0269 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

PI3K-Targeted Library (17255 compounds)

SH2 Library (10483 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Cancer
  • Endocrine
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with L438-0269 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L438-0269?
Check Price and Availability of L438-0269, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L438-0269 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L438-0269
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L438-0269
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L438-0269 available by request