L464-0540 Screening compound: 8-{[5-(3,4-dimethyl-1,2-oxazol-5-yl)thiophen-2-yl]sulfonyl}-1,4-dioxa-8-azaspiro[4.5]decane

L464-0540 Screening compound: 8-{[5-(3,4-dimethyl-1,2-oxazol-5-yl)thiophen-2-yl]sulfonyl}-1,4-dioxa-8-azaspiro[4.5]decane
L464-0540 Screening compound: 8-{[5-(3,4-dimethyl-1,2-oxazol-5-yl)thiophen-2-yl]sulfonyl}-1,4-dioxa-8-azaspiro[4.5]decane alternative view

Chemical Structure Depiction of ChemDiv screening compound L464-0540
8-{[5-(3,4-dimethyl-1,2-oxazol-5-yl)thiophen-2-yl]sulfonyl}-1,4-dioxa-8-azaspiro[4.5]decane

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L464-0540

Molecular Formula

C16H20N2O5S2 (C16 H20 N2 O5 S2)

Compound Name

8-{[5-(3,4-dimethyl-1,2-oxazol-5-yl)thiophen-2-yl]sulfonyl}-1,4-dioxa-8-azaspiro[4.5]decane

IUPAC name

8-{[5-(34-dimethyl-12-oxazol-5-yl)thiophen-2-yl]sulfonyl}-14-dioxa-8-azaspiro[4.5]decane

SMILES

Cc1c(-c(s2)ccc2S(N(CC2)CCC22OCCO2)(=O)=O)onc1C

InChI

InChI=1S/C16H20N2O5S2/c1-11-12(2)17-23-15(11)13-3-4-14(24-13)25(19,20)18-7-5-16(6-8-18)21-9-10-22-16/h3-4H,5-10H2,1-2H3

InChI Key

FFHGDGFXINFPPO-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27254568

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

384.48

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

3.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

2.652

Distribution Coefficient, logD

2.652

Water Solubility, LogSw

-2.81

Polar Surface Area

69.750

Acid Dissociation Constant (pKa)

24.60

Base Dissociation Constant (pKb)

-0.03

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

56.30

L464-0540 in Drug Discovery

Included in Screening Libraries

Protein Arginine Methyltransferases Library (27925 compounds)

Targeted Diversity Library (40567 compounds)

Akt-Targeted Library (14764 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Others
  • Kinases
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with L464-0540 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L464-0540?
Check Price and Availability of L464-0540, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L464-0540 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L464-0540
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L464-0540
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L464-0540 available by request