L475-0365 Screening compound: 3-ethyl-6-({4-[(2E)-3-(4-methylphenyl)prop-2-enoyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1,3-benzothiazol-2-one

L475-0365 Screening compound: 3-ethyl-6-({4-[(2E)-3-(4-methylphenyl)prop-2-enoyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1,3-benzothiazol-2-one
L475-0365 Screening compound: 3-ethyl-6-({4-[(2E)-3-(4-methylphenyl)prop-2-enoyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1,3-benzothiazol-2-one alternative view

Chemical Structure Depiction of ChemDiv screening compound L475-0365
3-ethyl-6-({4-[(2E)-3-(4-methylphenyl)prop-2-enoyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1,3-benzothiazol-2-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L475-0365

Molecular Formula

C23H25N3O4S2 (C23 H25 N3 O4 S2)

Compound Name

3-ethyl-6-({4-[(2E)-3-(4-methylphenyl)prop-2-enoyl]piperazin-1-yl}sulfonyl)-2,3-dihydro-1,3-benzothiazol-2-one

IUPAC name

3-ethyl-6-({4-[(2E)-3-(4-methylphenyl)prop-2-enoyl]piperazin-1-yl}sulfonyl)-23-dihydro-13-benzothiazol-2-one

SMILES

CCN(c(ccc(S(N(CC1)CCN1C(/C=C/c1ccc(C)cc1)=O)(=O)=O)c1)c1S1)C1=O

InChI

InChI=1S/C23H25N3O4S2/c1-3-26-20-10-9-19(16-21(20)31-23(26)28)32(29,30)25-14-12-24(13-15-25)22(27)11-8-18-6-4-17(2)5-7-18/h4-11,16H,3,12-15H2,1-2H3

InChI Key

TVZJCWWFTCKPHC-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27455326

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

471.6

Hydrogen Bond Acceptors Count

10.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.091

Distribution Coefficient, logD

4.091

Water Solubility, LogSw

-4.18

Polar Surface Area

63.447

Acid Dissociation Constant (pKa)

27.91

Base Dissociation Constant (pKb)

0.11

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

30.40

L475-0365 in Drug Discovery

Included in Screening Libraries

KRAS-Targeted Library (16000 compounds)

Covalent Inhibitors Library (7986 compounds)

?ysteine Targeted Covalent Library (39471 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases
Structure:
  • Cyclic compounds
  • 3D
  • Fragments

References: we are preparing a list of scientific research reports with L475-0365 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L475-0365?
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What is the minimum amount of L475-0365 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L475-0365
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L475-0365
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L475-0365 available by request