L482-1254 Screening compound: N-[2-(3-chlorophenyl)-4-methoxyquinolin-6-yl]-2-(thiophen-2-yl)acetamide

L482-1254 Screening compound: N-[2-(3-chlorophenyl)-4-methoxyquinolin-6-yl]-2-(thiophen-2-yl)acetamide
L482-1254 Screening compound: N-[2-(3-chlorophenyl)-4-methoxyquinolin-6-yl]-2-(thiophen-2-yl)acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L482-1254
N-[2-(3-chlorophenyl)-4-methoxyquinolin-6-yl]-2-(thiophen-2-yl)acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L482-1254

Molecular Formula

C22H17ClN2O2S (C22 H17 ClN2 O2 S)

Compound Name

N-[2-(3-chlorophenyl)-4-methoxyquinolin-6-yl]-2-(thiophen-2-yl)acetamide

IUPAC name

N-[2-(3-chlorophenyl)-4-methoxyquinolin-6-yl]-2-(thiophen-2-yl)acetamide

SMILES

COc(c1c2)cc(-c3cccc(Cl)c3)nc1ccc2NC(Cc1cccs1)=O

InChI

InChI=1S/C22H17ClN2O2S/c1-27-21-13-20(14-4-2-5-15(23)10-14)25-19-8-7-16(11-18(19)21)24-22(26)12-17-6-3-9-28-17/h2-11,13H,12H2,1H3,(H,24,26)

InChI Key

VGIUKXFEYZHDON-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27456202

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

408.91

Hydrogen Bond Acceptors Count

4.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

4

Partition Coefficient, logP

5.462

Distribution Coefficient, logD

5.461

Water Solubility, LogSw

-5.96

Polar Surface Area

39.824

Acid Dissociation Constant (pKa)

11.72

Base Dissociation Constant (pKb)

4.65

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

9.10

L482-1254 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

KRAS-Targeted Library (16000 compounds)

Protein-Protein Interaction Library (218420 compounds)

SmartTM Library (51161 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with L482-1254 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L482-1254?
Check Price and Availability of L482-1254, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L482-1254 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L482-1254
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L482-1254
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L482-1254 available by request