L483-0295 Screening compound: 4-(4-{1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl}piperidin-1-yl)-6,7-dimethoxyquinoline-3-carbonitrile

L483-0295 Screening compound: 4-(4-{1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl}piperidin-1-yl)-6,7-dimethoxyquinoline-3-carbonitrile
L483-0295 Screening compound: 4-(4-{1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl}piperidin-1-yl)-6,7-dimethoxyquinoline-3-carbonitrile alternative view

Chemical Structure Depiction of ChemDiv screening compound L483-0295
4-(4-{1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl}piperidin-1-yl)-6,7-dimethoxyquinoline-3-carbonitrile

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L483-0295

Molecular Formula

C25H30N4O5 (C25 H30 N4 O5)

Compound Name

4-(4-{1,4-dioxa-8-azaspiro[4.5]decane-8-carbonyl}piperidin-1-yl)-6,7-dimethoxyquinoline-3-carbonitrile

IUPAC name

4-(4-{14-dioxa-8-azaspiro[4.5]decane-8-carbonyl}piperidin-1-yl)-67-dimethoxyquinoline-3-carbonitrile

SMILES

COc(cc(c(nc1)c2)c(N(CC3)CCC3C(N(CC3)CCC33OCCO3)=O)c1C#N)c2OC

InChI

InChI=1S/C25H30N4O5/c1-31-21-13-19-20(14-22(21)32-2)27-16-18(15-26)23(19)28-7-3-17(4-8-28)24(30)29-9-5-25(6-10-29)33-11-12-34-25/h13-14,16-17H,3-12H2,1-2H3

InChI Key

MCEZLXRZQOQHIZ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD16639788

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

466.54

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

1.613

Distribution Coefficient, logD

1.560

Water Solubility, LogSw

-2.00

Polar Surface Area

75.344

Acid Dissociation Constant (pKa)

22.83

Base Dissociation Constant (pKb)

6.51

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

56.00

L483-0295 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Epigenetics Focused Set (26518 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Hemic and lymphatic
  • Cardiovascular

References: we are preparing a list of scientific research reports with L483-0295 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L483-0295?
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What is the minimum amount of L483-0295 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L483-0295
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L483-0295
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L483-0295 available by request