L483-0447 Screening compound: 1-(3-cyano-6-fluoroquinolin-4-yl)-N-(3,4,5-trimethoxyphenyl)piperidine-4-carboxamide

L483-0447 Screening compound: 1-(3-cyano-6-fluoroquinolin-4-yl)-N-(3,4,5-trimethoxyphenyl)piperidine-4-carboxamide
L483-0447 Screening compound: 1-(3-cyano-6-fluoroquinolin-4-yl)-N-(3,4,5-trimethoxyphenyl)piperidine-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L483-0447
1-(3-cyano-6-fluoroquinolin-4-yl)-N-(3,4,5-trimethoxyphenyl)piperidine-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L483-0447

Molecular Formula

C25H25FN4O4 (C25 H25 FN4 O4)

Compound Name

1-(3-cyano-6-fluoroquinolin-4-yl)-N-(3,4,5-trimethoxyphenyl)piperidine-4-carboxamide

IUPAC name

1-(3-cyano-6-fluoroquinolin-4-yl)-N-(345-trimethoxyphenyl)piperidine-4-carboxamide

SMILES

COc1cc(NC(C(CC2)CCN2c2c(cc(cc3)F)c3ncc2C#N)=O)cc(OC)c1OC

InChI

InChI=1S/C25H25FN4O4/c1-32-21-11-18(12-22(33-2)24(21)34-3)29-25(31)15-6-8-30(9-7-15)23-16(13-27)14-28-20-5-4-17(26)10-19(20)23/h4-5,10-12,14-15H,6-9H2,1-3H3,(H,29,31)

InChI Key

YJCBHOACKAENJW-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27456448

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

464.5

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

2.932

Distribution Coefficient, logD

2.929

Water Solubility, LogSw

-3.25

Polar Surface Area

75.067

Acid Dissociation Constant (pKa)

9.79

Base Dissociation Constant (pKb)

4.25

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

32.00

L483-0447 in Drug Discovery

Included in Screening Libraries

Antimitotic Tubulin Library (17355 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Nonpeptide Peptidomimetics PPI Library (18997 compounds)

Protein-Protein Interaction Library (218420 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Hemic and lymphatic
  • Cardiovascular
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics

References: we are preparing a list of scientific research reports with L483-0447 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L483-0447?
Check Price and Availability of L483-0447, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L483-0447 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L483-0447
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L483-0447
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L483-0447 available by request