L489-2319 Screening compound: 2-{7-chloro-6-fluoro-10-oxo-1H,2H,3H,4H,5H,10H-benzo[b]1,6-naphthyridin-2-yl}-N-(3-cyanophenyl)acetamide

L489-2319 Screening compound: 2-{7-chloro-6-fluoro-10-oxo-1H,2H,3H,4H,5H,10H-benzo[b]1,6-naphthyridin-2-yl}-N-(3-cyanophenyl)acetamide
L489-2319 Screening compound: 2-{7-chloro-6-fluoro-10-oxo-1H,2H,3H,4H,5H,10H-benzo[b]1,6-naphthyridin-2-yl}-N-(3-cyanophenyl)acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L489-2319
2-{7-chloro-6-fluoro-10-oxo-1H,2H,3H,4H,5H,10H-benzo[b]1,6-naphthyridin-2-yl}-N-(3-cyanophenyl)acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L489-2319

Molecular Formula

C21H16ClFN4O2 (C21 H16 ClFN4 O2)

Compound Name

2-{7-chloro-6-fluoro-10-oxo-1H,2H,3H,4H,5H,10H-benzo[b]1,6-naphthyridin-2-yl}-N-(3-cyanophenyl)acetamide

IUPAC name

2-{7-chloro-6-fluoro-10-oxo-1H2H3H4H5H10H-benzo[b]16-naphthyridin-2-yl}-N-(3-cyanophenyl)acetamide

SMILES

N#Cc1cccc(NC(CN(CC2)CC3=C2Nc(c(F)c(cc2)Cl)c2C3=O)=O)c1

InChI

InChI=1S/C21H16ClFN4O2/c22-16-5-4-14-20(19(16)23)26-17-6-7-27(10-15(17)21(14)29)11-18(28)25-13-3-1-2-12(8-13)9-24/h1-5,8H,6-7,10-11H2,(H,25,28)(H,26,29)

InChI Key

LQUGJRHBLGZQEB-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27457787

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

410.83

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

3.759

Distribution Coefficient, logD

1.273

Water Solubility, LogSw

-4.40

Polar Surface Area

65.867

Acid Dissociation Constant (pKa)

4.92

Base Dissociation Constant (pKb)

1.69

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

19.00

L489-2319 in Drug Discovery

Included in Screening Libraries

RAR (Nuclear receptors) Ligands Library (6524 compounds)

SmartTM Library (51161 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Respiratory tract
  • Eye
  • Male
  • Female
  • Hemic and lymphatic
  • Congenital
  • Skin
  • Endocrine
  • Immune system
Targets:
  • Nuclear receptors
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with L489-2319 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L489-2319?
Check Price and Availability of L489-2319, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L489-2319 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L489-2319
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L489-2319
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L489-2319 available by request