L507-0437 Screening compound: N-(2,4-difluorophenyl)-1,2-dimethyl-5-[4-methyl-5-(piperidine-1-carbonyl)-1,3-thiazol-2-yl]-1H-pyrrole-3-sulfonamide

L507-0437 Screening compound: N-(2,4-difluorophenyl)-1,2-dimethyl-5-[4-methyl-5-(piperidine-1-carbonyl)-1,3-thiazol-2-yl]-1H-pyrrole-3-sulfonamide
L507-0437 Screening compound: N-(2,4-difluorophenyl)-1,2-dimethyl-5-[4-methyl-5-(piperidine-1-carbonyl)-1,3-thiazol-2-yl]-1H-pyrrole-3-sulfonamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L507-0437
N-(2,4-difluorophenyl)-1,2-dimethyl-5-[4-methyl-5-(piperidine-1-carbonyl)-1,3-thiazol-2-yl]-1H-pyrrole-3-sulfonamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L507-0437

Molecular Formula

C22H24F2N4O3S2 (C22 H24 F2 N4 O3 S2)

Compound Name

N-(2,4-difluorophenyl)-1,2-dimethyl-5-[4-methyl-5-(piperidine-1-carbonyl)-1,3-thiazol-2-yl]-1H-pyrrole-3-sulfonamide

IUPAC name

N-(24-difluorophenyl)-12-dimethyl-5-[4-methyl-5-(piperidine-1-carbonyl)-13-thiazol-2-yl]-1H-pyrrole-3-sulfonamide

SMILES

Cc(n(C)c(-c1nc(C)c(C(N2CCCCC2)=O)s1)c1)c1S(Nc(ccc(F)c1)c1F)(=O)=O

InChI

InChI=1S/C22H24F2N4O3S2/c1-13-20(22(29)28-9-5-4-6-10-28)32-21(25-13)18-12-19(14(2)27(18)3)33(30,31)26-17-8-7-15(23)11-16(17)24/h7-8,11-12,26H,4-6,9-10H2,1-3H3

InChI Key

XRUITCLQLBOZNZ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27459260

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

494.59

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

3.862

Distribution Coefficient, logD

2.148

Water Solubility, LogSw

-3.85

Polar Surface Area

69.182

Acid Dissociation Constant (pKa)

5.69

Base Dissociation Constant (pKb)

2.36

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

36.40

L507-0437 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

KRAS-Targeted Library (16000 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with L507-0437 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L507-0437?
Check Price and Availability of L507-0437, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L507-0437 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L507-0437
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L507-0437
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L507-0437 available by request