L575-0177 Screening compound: 1-[1-methyl-3-(pyrrolidine-1-carbonyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]-4-[4-(pyridin-2-yl)piperazin-1-yl]butane-1,4-dione

L575-0177 Screening compound: 1-[1-methyl-3-(pyrrolidine-1-carbonyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]-4-[4-(pyridin-2-yl)piperazin-1-yl]butane-1,4-dione
L575-0177 Screening compound: 1-[1-methyl-3-(pyrrolidine-1-carbonyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]-4-[4-(pyridin-2-yl)piperazin-1-yl]butane-1,4-dione alternative view

Chemical Structure Depiction of ChemDiv screening compound L575-0177
1-[1-methyl-3-(pyrrolidine-1-carbonyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]-4-[4-(pyridin-2-yl)piperazin-1-yl]butane-1,4-dione

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L575-0177

Molecular Formula

C25H33N7O3 (C25 H33 N7 O3)

Compound Name

1-[1-methyl-3-(pyrrolidine-1-carbonyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]-4-[4-(pyridin-2-yl)piperazin-1-yl]butane-1,4-dione

IUPAC name

1-[1-methyl-3-(pyrrolidine-1-carbonyl)-1H4H5H6H7H-pyrazolo[43-c]pyridin-5-yl]-4-[4-(pyridin-2-yl)piperazin-1-yl]butane-14-dione

SMILES

Cn1nc(C(N2CCCC2)=O)c(C2)c1CCN2C(CCC(N(CC1)CCN1c1ncccc1)=O)=O

InChI

InChI=1S/C25H33N7O3/c1-28-20-9-13-32(18-19(20)24(27-28)25(35)31-11-4-5-12-31)23(34)8-7-22(33)30-16-14-29(15-17-30)21-6-2-3-10-26-21/h2-3,6,10H,4-5,7-9,11-18H2,1H3

InChI Key

MVHCUGHYIFDIHY-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27463482

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

479.58

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

10

Partition Coefficient, logP

0.271

Distribution Coefficient, logD

0.262

Water Solubility, LogSw

-1.13

Polar Surface Area

76.217

Acid Dissociation Constant (pKa)

22.09

Base Dissociation Constant (pKb)

5.71

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

56.00

L575-0177 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Cysteine Proteases Inhibitors Library (7839 compounds)

GPCR Targeted Library (31838 compounds)

Hsp90-Targeted Library (11355 compounds)

SmartTM Library (51161 compounds)

Targeted Diversity Library (40567 compounds)

Epigenetics Focused Set (26518 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Nervous system
  • Cardiovascular
  • Skin
  • Metabolic
  • Endocrine
  • Immune system
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system
Targets:
  • Proteases
  • GPCR
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with L575-0177 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L575-0177?
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What is the minimum amount of L575-0177 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L575-0177
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L575-0177
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L575-0177 available by request