L627-1077 Screening compound: N-[(2,4-difluorophenyl)methyl]-4-{[1-methyl-3-(pyrrolidine-1-carbonyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]methyl}benzamide

L627-1077 Screening compound: N-[(2,4-difluorophenyl)methyl]-4-{[1-methyl-3-(pyrrolidine-1-carbonyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]methyl}benzamide
L627-1077 Screening compound: N-[(2,4-difluorophenyl)methyl]-4-{[1-methyl-3-(pyrrolidine-1-carbonyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]methyl}benzamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L627-1077
N-[(2,4-difluorophenyl)methyl]-4-{[1-methyl-3-(pyrrolidine-1-carbonyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]methyl}benzamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L627-1077

Molecular Formula

C27H29F2N5O2 (C27 H29 F2 N5 O2)

Compound Name

N-[(2,4-difluorophenyl)methyl]-4-{[1-methyl-3-(pyrrolidine-1-carbonyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]methyl}benzamide

IUPAC name

N-[(24-difluorophenyl)methyl]-4-{[1-methyl-3-(pyrrolidine-1-carbonyl)-1H4H5H6H7H-pyrazolo[43-c]pyridin-5-yl]methyl}benzamide

SMILES

Cn1nc(C(N2CCCC2)=O)c2c1CCN(Cc(cc1)ccc1C(NCc(ccc(F)c1)c1F)=O)C2

InChI

InChI=1S/C27H29F2N5O2/c1-32-24-10-13-33(17-22(24)25(31-32)27(36)34-11-2-3-12-34)16-18-4-6-19(7-5-18)26(35)30-15-20-8-9-21(28)14-23(20)29/h4-9,14H,2-3,10-13,15-17H2,1H3,(H,30,35)

InChI Key

NQVHKXLMJGAAQF-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27466126

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

493.56

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

2.685

Distribution Coefficient, logD

-3.634

Water Solubility, LogSw

-3.06

Polar Surface Area

60.078

Acid Dissociation Constant (pKa)

11.18

Base Dissociation Constant (pKb)

13.72

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

37.00

L627-1077 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Cysteine Proteases Inhibitors Library (7839 compounds)

GPCR Targeted Library (31838 compounds)

Hsp90-Targeted Library (11355 compounds)

Ion Channels Focused Library (26372 compounds)

New Agro Library (44492 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Nervous system
  • Cardiovascular
  • Skin
  • Metabolic
  • Endocrine
  • Immune system
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system
  • Nervous system
  • Cardiovascular
Targets:
  • Proteases
  • GPCR
  • Ion Channels
Mechanism of action:
  • Receptor's ligands
Agro:
  • Agro

References: we are preparing a list of scientific research reports with L627-1077 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L627-1077?
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What is the minimum amount of L627-1077 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L627-1077
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L627-1077
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L627-1077 available by request