L632-1146 Screening compound: N-cyclopropyl-1-[5-(3-fluorobenzoyl)-1-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-3-carbonyl]piperidine-3-carboxamide

L632-1146 Screening compound: N-cyclopropyl-1-[5-(3-fluorobenzoyl)-1-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-3-carbonyl]piperidine-3-carboxamide
L632-1146 Screening compound: N-cyclopropyl-1-[5-(3-fluorobenzoyl)-1-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-3-carbonyl]piperidine-3-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L632-1146
N-cyclopropyl-1-[5-(3-fluorobenzoyl)-1-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-3-carbonyl]piperidine-3-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L632-1146

Molecular Formula

C24H28FN5O3 (C24 H28 FN5 O3)

Compound Name

N-cyclopropyl-1-[5-(3-fluorobenzoyl)-1-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-3-carbonyl]piperidine-3-carboxamide

IUPAC name

N-cyclopropyl-1-[5-(3-fluorobenzoyl)-1-methyl-1H4H5H6H7H-pyrazolo[43-c]pyridine-3-carbonyl]piperidine-3-carboxamide

SMILES

Cn1nc(C(N(CCC2)CC2C(NC2CC2)=O)=O)c(C2)c1CCN2C(c1cccc(F)c1)=O

InChI

InChI=1S/C24H28FN5O3/c1-28-20-9-11-30(23(32)15-4-2-6-17(25)12-15)14-19(20)21(27-28)24(33)29-10-3-5-16(13-29)22(31)26-18-7-8-18/h2,4,6,12,16,18H,3,5,7-11,13-14H2,1H3,(H,26,31)/t16-/m0/s1

InChI Key

WGOPGKLMHQWQST-INIZCTEOSA-N

MDL Number (MFCD)

MFCD27466764

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

453.52

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

0.610

Distribution Coefficient, logD

0.610

Water Solubility, LogSw

-2.03

Polar Surface Area

72.618

Acid Dissociation Constant (pKa)

13.13

Base Dissociation Constant (pKb)

1.09

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

50.00

L632-1146 in Drug Discovery

Included in Screening Libraries

3D-Diversity Natural-Product-Like Library (18102 compounds)

Anticancer Library (62698 compounds)

Cysteine Proteases Inhibitors Library (7839 compounds)

Hsp90-Targeted Library (11355 compounds)

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

SmartTM Library (51161 compounds)

Targeted Diversity Library (40567 compounds)

Peptidomimetic Library (37031 compounds)

Included in 1.7M Stock Database

Structure:
  • 3D
  • Mimetics
  • Mimetics
Therapeutical areas:
  • Cancer
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Nervous system
  • Cardiovascular
  • Skin
  • Metabolic
  • Endocrine
  • Immune system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system
Targets:
  • Proteases
Mechanism of action:
  • PPI modulators
  • PPI modulators

References: we are preparing a list of scientific research reports with L632-1146 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L632-1146?
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What is the minimum amount of L632-1146 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L632-1146
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L632-1146
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L632-1146 available by request