L637-0618 Screening compound: 2-[2-(morpholin-4-yl)pyridin-4-yl]-N-(3,4,5-trimethoxyphenyl)-1,3-thiazole-4-carboxamide

L637-0618 Screening compound: 2-[2-(morpholin-4-yl)pyridin-4-yl]-N-(3,4,5-trimethoxyphenyl)-1,3-thiazole-4-carboxamide
L637-0618 Screening compound: 2-[2-(morpholin-4-yl)pyridin-4-yl]-N-(3,4,5-trimethoxyphenyl)-1,3-thiazole-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L637-0618
2-[2-(morpholin-4-yl)pyridin-4-yl]-N-(3,4,5-trimethoxyphenyl)-1,3-thiazole-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L637-0618

Molecular Formula

C22H24N4O5S (C22 H24 N4 O5 S)

Compound Name

2-[2-(morpholin-4-yl)pyridin-4-yl]-N-(3,4,5-trimethoxyphenyl)-1,3-thiazole-4-carboxamide

IUPAC name

2-[2-(morpholin-4-yl)pyridin-4-yl]-N-(345-trimethoxyphenyl)-13-thiazole-4-carboxamide

SMILES

COc1cc(NC(c2csc(-c3cc(N4CCOCC4)ncc3)n2)=O)cc(OC)c1OC

InChI

InChI=1S/C22H24N4O5S/c1-28-17-11-15(12-18(29-2)20(17)30-3)24-21(27)16-13-32-22(25-16)14-4-5-23-19(10-14)26-6-8-31-9-7-26/h4-5,10-13H,6-9H2,1-3H3,(H,24,27)

InChI Key

RYLSSGZTRJJJMH-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27466960

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

456.52

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

3.222

Distribution Coefficient, logD

3.213

Water Solubility, LogSw

-3.53

Polar Surface Area

75.914

Acid Dissociation Constant (pKa)

10.26

Base Dissociation Constant (pKb)

5.68

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

31.80

L637-0618 in Drug Discovery

Included in Screening Libraries

CNS Targets (44014 compounds)

Ion Channels Focused Library (26372 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Nervous system
  • Cardiovascular
Targets:
  • Ion Channels

References: we are preparing a list of scientific research reports with L637-0618 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L637-0618?
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What is the minimum amount of L637-0618 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L637-0618
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L637-0618
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L637-0618 available by request