L680-0270 Screening compound: 1-[(5-chlorothiophen-2-yl)sulfonyl]-4-{[3-(3,5-dimethylphenyl)-3H-imidazo[4,5-b]pyridin-2-yl]methyl}piperazine

L680-0270 Screening compound: 1-[(5-chlorothiophen-2-yl)sulfonyl]-4-{[3-(3,5-dimethylphenyl)-3H-imidazo[4,5-b]pyridin-2-yl]methyl}piperazine
L680-0270 Screening compound: 1-[(5-chlorothiophen-2-yl)sulfonyl]-4-{[3-(3,5-dimethylphenyl)-3H-imidazo[4,5-b]pyridin-2-yl]methyl}piperazine alternative view

Chemical Structure Depiction of ChemDiv screening compound L680-0270
1-[(5-chlorothiophen-2-yl)sulfonyl]-4-{[3-(3,5-dimethylphenyl)-3H-imidazo[4,5-b]pyridin-2-yl]methyl}piperazine

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L680-0270

Molecular Formula

C23H24ClN5O2S2 (C23 H24 ClN5 O2 S2)

Compound Name

1-[(5-chlorothiophen-2-yl)sulfonyl]-4-{[3-(3,5-dimethylphenyl)-3H-imidazo[4,5-b]pyridin-2-yl]methyl}piperazine

IUPAC name

1-[(5-chlorothiophen-2-yl)sulfonyl]-4-{[3-(35-dimethylphenyl)-3H-imidazo[45-b]pyridin-2-yl]methyl}piperazine

SMILES

Cc1cc(-n2c(nccc3)c3nc2CN(CC2)CCN2S(c(s2)ccc2Cl)(=O)=O)cc(C)c1

InChI

InChI=1S/C23H24ClN5O2S2/c1-16-12-17(2)14-18(13-16)29-21(26-19-4-3-7-25-23(19)29)15-27-8-10-28(11-9-27)33(30,31)22-6-5-20(24)32-22/h3-7,12-14H,8-11,15H2,1-2H3

InChI Key

FUOCJTSVLJNPTC-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15133235

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

502.06

Hydrogen Bond Acceptors Count

8.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.281

Distribution Coefficient, logD

4.241

Water Solubility, LogSw

-4.44

Polar Surface Area

58.063

Acid Dissociation Constant (pKa)

28.07

Base Dissociation Constant (pKb)

6.39

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

30.40

L680-0270 in Drug Discovery

Included in Screening Libraries

Chelators targeting matrix metalloproteinases library (8930 compounds)

PI3K-Targeted Library (17255 compounds)

Epigenetics Focused Set (26518 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Cardiovascular
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Proteases
  • Kinases

References: we are preparing a list of scientific research reports with L680-0270 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L680-0270?
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What is the minimum amount of L680-0270 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L680-0270
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L680-0270
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L680-0270 available by request