L681-0283 Screening compound: 2-{6-[(4-fluorophenyl)methyl]-2-methyl-5,7-dioxo-2H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidin-4-yl}-N-(3,4,5-trimethoxyphenyl)acetamide

L681-0283 Screening compound: 2-{6-[(4-fluorophenyl)methyl]-2-methyl-5,7-dioxo-2H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidin-4-yl}-N-(3,4,5-trimethoxyphenyl)acetamide
L681-0283 Screening compound: 2-{6-[(4-fluorophenyl)methyl]-2-methyl-5,7-dioxo-2H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidin-4-yl}-N-(3,4,5-trimethoxyphenyl)acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L681-0283
2-{6-[(4-fluorophenyl)methyl]-2-methyl-5,7-dioxo-2H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidin-4-yl}-N-(3,4,5-trimethoxyphenyl)acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L681-0283

Molecular Formula

C24H24FN5O6 (C24 H24 FN5 O6)

Compound Name

2-{6-[(4-fluorophenyl)methyl]-2-methyl-5,7-dioxo-2H,4H,5H,6H,7H-pyrazolo[4,3-d]pyrimidin-4-yl}-N-(3,4,5-trimethoxyphenyl)acetamide

IUPAC name

2-{6-[(4-fluorophenyl)methyl]-2-methyl-57-dioxo-2H4H5H6H7H-pyrazolo[43-d]pyrimidin-4-yl}-N-(345-trimethoxyphenyl)acetamide

SMILES

Cn(cc1N(CC(Nc(cc2OC)cc(OC)c2OC)=O)C(N2Cc(cc3)ccc3F)=O)nc1C2=O

InChI

InChI=1S/C24H24FN5O6/c1-28-12-17-21(27-28)23(32)30(11-14-5-7-15(25)8-6-14)24(33)29(17)13-20(31)26-16-9-18(34-2)22(36-4)19(10-16)35-3/h5-10,12H,11,13H2,1-4H3,(H,26,31)

InChI Key

MHBPGHCLIVQKAJ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15133302

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

497.48

Hydrogen Bond Acceptors Count

10.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

9.00

Number of Nitrogen and Oxygen Atoms

11

Partition Coefficient, logP

1.789

Distribution Coefficient, logD

1.788

Water Solubility, LogSw

-2.54

Polar Surface Area

92.840

Acid Dissociation Constant (pKa)

10.51

Base Dissociation Constant (pKb)

1.48

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

25.00

L681-0283 in Drug Discovery

Included in Screening Libraries

Antimitotic Tubulin Library (17355 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin

References: we are preparing a list of scientific research reports with L681-0283 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L681-0283?
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What is the minimum amount of L681-0283 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L681-0283
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L681-0283
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L681-0283 available by request