L708-0868 Screening compound: 2-[6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-1-[4-(2,3-dimethylphenyl)piperazin-1-yl]ethan-1-one

L708-0868 Screening compound: 2-[6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-1-[4-(2,3-dimethylphenyl)piperazin-1-yl]ethan-1-one
L708-0868 Screening compound: 2-[6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-1-[4-(2,3-dimethylphenyl)piperazin-1-yl]ethan-1-one alternative view

Chemical Structure Depiction of ChemDiv screening compound L708-0868
2-[6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-1-[4-(2,3-dimethylphenyl)piperazin-1-yl]ethan-1-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L708-0868

Molecular Formula

C25H25ClN4OS (C25 H25 ClN4 OS)

Compound Name

2-[6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-1-[4-(2,3-dimethylphenyl)piperazin-1-yl]ethan-1-one

IUPAC name

2-[6-(4-chlorophenyl)imidazo[21-b][13]thiazol-3-yl]-1-[4-(23-dimethylphenyl)piperazin-1-yl]ethan-1-one

SMILES

Cc1cccc(N(CC2)CCN2C(Cc2csc3nc(-c(cc4)ccc4Cl)cn23)=O)c1C

InChI

InChI=1S/C25H25ClN4OS/c1-17-4-3-5-23(18(17)2)28-10-12-29(13-11-28)24(31)14-21-16-32-25-27-22(15-30(21)25)19-6-8-20(26)9-7-19/h3-9,15-16H,10-14H2,1-2H3

InChI Key

XJDNTJLMUMHOGQ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27472184

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

465.02

Hydrogen Bond Acceptors Count

3.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

5.964

Distribution Coefficient, logD

5.964

Water Solubility, LogSw

-6.17

Polar Surface Area

28.257

Acid Dissociation Constant (pKa)

19.92

Base Dissociation Constant (pKb)

4.20

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

28.00

L708-0868 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

MDM2-p53 interaction inhibitors Library (21687 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with L708-0868 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L708-0868?
Check Price and Availability of L708-0868, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L708-0868 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L708-0868
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L708-0868
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L708-0868 available by request