L708-1974 Screening compound: N-(5-chloropyridin-2-yl)-2-[6-(3,4-dimethoxyphenyl)imidazo[2,1-b][1,3]thiazol-3-yl]acetamide

L708-1974 Screening compound: N-(5-chloropyridin-2-yl)-2-[6-(3,4-dimethoxyphenyl)imidazo[2,1-b][1,3]thiazol-3-yl]acetamide
L708-1974 Screening compound: N-(5-chloropyridin-2-yl)-2-[6-(3,4-dimethoxyphenyl)imidazo[2,1-b][1,3]thiazol-3-yl]acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L708-1974
N-(5-chloropyridin-2-yl)-2-[6-(3,4-dimethoxyphenyl)imidazo[2,1-b][1,3]thiazol-3-yl]acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L708-1974

Molecular Formula

C20H17ClN4O3S (C20 H17 ClN4 O3 S)

Compound Name

N-(5-chloropyridin-2-yl)-2-[6-(3,4-dimethoxyphenyl)imidazo[2,1-b][1,3]thiazol-3-yl]acetamide

IUPAC name

N-(5-chloropyridin-2-yl)-2-[6-(34-dimethoxyphenyl)imidazo[21-b][13]thiazol-3-yl]acetamide

SMILES

COc(ccc(-c1cn(c(CC(Nc(cc2)ncc2Cl)=O)cs2)c2n1)c1)c1OC

InChI

InChI=1S/C20H17ClN4O3S/c1-27-16-5-3-12(7-17(16)28-2)15-10-25-14(11-29-20(25)23-15)8-19(26)24-18-6-4-13(21)9-22-18/h3-7,9-11H,8H2,1-2H3,(H,22,24,26)

InChI Key

UTHXJJPIODGRQG-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27472256

Chemical and Physical Properties

Saltdata

HCl

Molecular Weight

428.9

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.102

Distribution Coefficient, logD

4.080

Water Solubility, LogSw

-4.48

Polar Surface Area

57.019

Acid Dissociation Constant (pKa)

8.80

Base Dissociation Constant (pKb)

5.52

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

15.00

L708-1974 in Drug Discovery

Included in Screening Libraries

Anticancer Library (62698 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

SmartTM Library (51161 compounds)

Akt-Targeted Library (14764 compounds)

MDM2-p53 interaction inhibitors Library (21687 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Cancer
Targets:
  • Kinases
  • Kinases
Mechanism of action:
  • PPI modulators

References: we are preparing a list of scientific research reports with L708-1974 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L708-1974?
Check Price and Availability of L708-1974, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L708-1974 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L708-1974
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L708-1974
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L708-1974 available by request