L708-2044 Screening compound: 2-[6-(3,4-dimethoxyphenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one

L708-2044 Screening compound: 2-[6-(3,4-dimethoxyphenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one
L708-2044 Screening compound: 2-[6-(3,4-dimethoxyphenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one alternative view

Chemical Structure Depiction of ChemDiv screening compound L708-2044
2-[6-(3,4-dimethoxyphenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L708-2044

Molecular Formula

C24H23N3O3S (C24 H23 N3 O3 S)

Compound Name

2-[6-(3,4-dimethoxyphenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one

IUPAC name

2-[6-(34-dimethoxyphenyl)imidazo[21-b][13]thiazol-3-yl]-1-(1234-tetrahydroisoquinolin-2-yl)ethan-1-one

SMILES

COc(ccc(-c1cn(c(CC(N(CC2)Cc3c2cccc3)=O)cs2)c2n1)c1)c1OC

InChI

InChI=1S/C24H23N3O3S/c1-29-21-8-7-17(11-22(21)30-2)20-14-27-19(15-31-24(27)25-20)12-23(28)26-10-9-16-5-3-4-6-18(16)13-26/h3-8,11,14-15H,9-10,12-13H2,1-2H3

InChI Key

FXFVBYFSBXHZRG-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27472289

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

433.53

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

6.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

4.068

Distribution Coefficient, logD

4.063

Water Solubility, LogSw

-4.15

Polar Surface Area

40.220

Acid Dissociation Constant (pKa)

19.08

Base Dissociation Constant (pKb)

5.52

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

25.00

L708-2044 in Drug Discovery

Included in Screening Libraries

Anti-Aging Library (44940 compounds)

Anticancer Library (62698 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

SmartTM Library (51161 compounds)

MDM2-p53 interaction inhibitors Library (21687 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Metabolic
  • Immune system
  • Cancer
  • Cancer
Mechanism of action:
  • Epigenetic
  • PPI modulators

References: we are preparing a list of scientific research reports with L708-2044 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L708-2044?
Check Price and Availability of L708-2044, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L708-2044 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L708-2044
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L708-2044
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L708-2044 available by request