L728-0203 Screening compound: 1-(CYCLOPROPYLCARBONYL)-N~2~-[2-(2-PHENYL-1,3-THIAZOL-4-YL)ETHYL]-2-PYRROLIDINECARBOXAMIDE

L728-0203 Screening compound: 1-(CYCLOPROPYLCARBONYL)-N~2~-[2-(2-PHENYL-1,3-THIAZOL-4-YL)ETHYL]-2-PYRROLIDINECARBOXAMIDE
L728-0203 Screening compound: 1-(CYCLOPROPYLCARBONYL)-N~2~-[2-(2-PHENYL-1,3-THIAZOL-4-YL)ETHYL]-2-PYRROLIDINECARBOXAMIDE alternative view

Chemical Structure Depiction of ChemDiv screening compound L728-0203
1-(CYCLOPROPYLCARBONYL)-N~2~-[2-(2-PHENYL-1,3-THIAZOL-4-YL)ETHYL]-2-PYRROLIDINECARBOXAMIDE

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L728-0203

Molecular Formula

C20H23N3O2S (C20 H23 N3 O2 S)

Compound Name

1-(CYCLOPROPYLCARBONYL)-N~2~-[2-(2-PHENYL-1,3-THIAZOL-4-YL)ETHYL]-2-PYRROLIDINECARBOXAMIDE

IUPAC name

n/a

SMILES

O=C(C1CC1)N(CCC1)C1C(NCCc1csc(-c2ccccc2)n1)=O

InChI

InChI=1S/C20H23N3O2S/c24-18(17-7-4-12-23(17)20(25)15-8-9-15)21-11-10-16-13-26-19(22-16)14-5-2-1-3-6-14/h1-3,5-6,13,15,17H,4,7-12H2,(H,21,24)/t17-/m0/s1

InChI Key

FKIOOTIJNSCOMY-KRWDZBQOSA-N

MDL Number (MFCD)

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

369.49

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

2.830

Distribution Coefficient, logD

2.830

Water Solubility, LogSw

-3.29

Polar Surface Area

51.954

Acid Dissociation Constant (pKa)

14.30

Base Dissociation Constant (pKb)

1.76

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

45.00

L728-0203 in Drug Discovery

Included in Screening Libraries

3D Mimetics PPI Library (1617 compounds)

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

GPCR Targeted Library (31838 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Nonpeptide Peptidomimetics PPI Library (18997 compounds)

PI3K-Targeted Library (17255 compounds)

Protein-Protein Interaction Library (218420 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Included in 1.7M Stock Database

Structure:
  • Mimetics
  • 3D
  • Mimetics
  • Cyclic compounds
Therapeutical areas:
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Hemic and lymphatic
  • Cardiovascular
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
Targets:
  • GPCR
  • Kinases
  • Proteases
Mechanism of action:
  • Receptor's ligands
  • PPI modulators
  • PPI modulators

References: we are preparing a list of scientific research reports with L728-0203 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L728-0203?
Check Price and Availability of L728-0203, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L728-0203 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L728-0203
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L728-0203
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L728-0203 available by request