L728-0284 Screening compound: 1-[(3-METHYLPHENOXY)ACETYL]-N-[2-(2-PHENYL-1,3-THIAZOL-4-YL)ETHYL]PROLINAMIDE

Chemical Structure Depiction of ChemDiv screening compound L728-0284
1-[(3-METHYLPHENOXY)ACETYL]-N-[2-(2-PHENYL-1,3-THIAZOL-4-YL)ETHYL]PROLINAMIDE

Available from 1 mg

Formats:

Glass Vials (4ml Glass Vials VWR #97047-678)
96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Check Price and Availability

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L728-0284

Molecular Formula

C₂₅H₂₇N₃O₃S (C25 H27 N3 O3 S)

Compound Name

1-[(3-METHYLPHENOXY)ACETYL]-N-[2-(2-PHENYL-1,3-THIAZOL-4-YL)ETHYL]PROLINAMIDE

IUPAC name

n/a

SMILES

Cc1cccc(OCC(N(CCC2)C2C(NCCc2csc(-c3ccccc3)n2)=O)=O)c1

InChI

InChI=1S/C25H27N3O3S/c1-18-7-5-10-21(15-18)31-16-23(29)28-14-6-11-22(28)24(30)26-13-12-20-17-32-25(27-20)19-8-3-2-4-9-19/h2-5,7-10,15,17,22H,6,11-14,16H2,1H3,(H,26,30)/t22-/m0/s1

InChI Key

LGCWDIWVCFEGNE-QFIPXVFZSA-N

MDL Number (MFCD)

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

449.57

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

10.00

Number of Nitrogen and Oxygen Atoms

Partition Coefficient, logP

3.914

Distribution Coefficient, logD

3.914

Water Solubility, LogSw

-3.87

Polar Surface Area

58.402

Acid Dissociation Constant (pK_a)

14.30

Base Dissociation Constant (pK_b)

1.76

Number of Chiral Centers

1.00

Percent sp³ carbon bonding

32.00

L728-0284 in Drug Discovery

Included in Screening Libraries

3D Mimetics PPI Library (1617 compounds)

Antiviral Library (67538 compounds)

GPCR Targeted Library (31838 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

PI3K-Targeted Library (17255 compounds)

PPI Inhibitors Tripeptide Mimetics (23972 compounds)

Protein-Protein Interaction Library (218420 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

SmartTM Library (51161 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Epigenetics Focused Set (26518 compounds)

Peptidomimetic Library (37031 compounds)

Included in 1.7M Stock Database

Structure:

Mimetics
3D
Mimetics
Cyclic compounds
Mimetics

Therapeutical areas:

Antiviral
Infections
Immune system
Musculoskeletal
Respiratory tract
Nervous system
Congenital
Skin
Metabolic
Endocrine
Hemic and lymphatic
Cardiovascular
Cancer
Digestive system
Respiratory tract
Otorhinolaryngologic
Male
Female
Hemic and lymphatic
Skin
Infections
Cancer
Musculoskeletal
Digestive system
Respiratory tract
Male
Female
Cardiovascular
Skin
Metabolic
Immune system

Targets:

GPCR
Kinases
Proteases

Mechanism of action:

Receptor's ligands
PPI modulators
PPI modulators
PPI modulators

References: we are preparing a list of scientific research reports with L728-0284 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L728-0284?
Check Price and Availability of L728-0284, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.

What is the minimum amount of L728-0284 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.

Delivery options for L728-0284
ChemDiv sends parcels with Express services (UPS, WC).

1–2 days for small orders
2–4 weeks for large selections

Delivery formats for L728-0284

0.5–50 mg of dry powder sample in single glass vials, custom vials
DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L728-0284 available by request