L857-1009 Screening compound: N-[(3,4-dimethoxyphenyl)methyl]-1-[4-(morpholin-4-yl)phthalazin-1-yl]piperidine-4-carboxamide

L857-1009 Screening compound: N-[(3,4-dimethoxyphenyl)methyl]-1-[4-(morpholin-4-yl)phthalazin-1-yl]piperidine-4-carboxamide
L857-1009 Screening compound: N-[(3,4-dimethoxyphenyl)methyl]-1-[4-(morpholin-4-yl)phthalazin-1-yl]piperidine-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L857-1009
N-[(3,4-dimethoxyphenyl)methyl]-1-[4-(morpholin-4-yl)phthalazin-1-yl]piperidine-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L857-1009

Molecular Formula

C27H33N5O4 (C27 H33 N5 O4)

Compound Name

N-[(3,4-dimethoxyphenyl)methyl]-1-[4-(morpholin-4-yl)phthalazin-1-yl]piperidine-4-carboxamide

IUPAC name

N-[(34-dimethoxyphenyl)methyl]-1-[4-(morpholin-4-yl)phthalazin-1-yl]piperidine-4-carboxamide

SMILES

COc(ccc(CNC(C(CC1)CCN1c(c1ccccc11)nnc1N1CCOCC1)=O)c1)c1OC

InChI

InChI=1S/C27H33N5O4/c1-34-23-8-7-19(17-24(23)35-2)18-28-27(33)20-9-11-31(12-10-20)25-21-5-3-4-6-22(21)26(30-29-25)32-13-15-36-16-14-32/h3-8,17,20H,9-16,18H2,1-2H3,(H,28,33)

InChI Key

HCZUQJAMIJUJBC-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27480870

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

491.59

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

2.787

Distribution Coefficient, logD

2.787

Water Solubility, LogSw

-3.23

Polar Surface Area

76.063

Acid Dissociation Constant (pKa)

14.07

Base Dissociation Constant (pKb)

4.19

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

44.40

L857-1009 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

CNS Targets (44014 compounds)

CORONAVIRUS Library (20774 compounds)

GPCR Targeted Library (31838 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Protein Kinases Inhibitors Library (36801 compounds)

Akt-Targeted Library (14764 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Antiviral
  • Infections
  • Immune system
  • Musculoskeletal
  • Respiratory tract
  • Nervous system
  • Congenital
  • Skin
  • Metabolic
  • Endocrine
  • Hemic and lymphatic
  • Cardiovascular
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Nervous system
  • Hemic and lymphatic
  • Cardiovascular
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • GPCR
  • Kinases
  • Kinases
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with L857-1009 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L857-1009?
Check Price and Availability of L857-1009, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L857-1009 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L857-1009
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L857-1009
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L857-1009 available by request