L859-0354 Screening compound: 2-{7-methyl-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]-4-oxo-1,4-dihydro-1,8-naphthyridin-1-yl}-N-[3-(methylsulfanyl)phenyl]acetamide

L859-0354 Screening compound: 2-{7-methyl-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]-4-oxo-1,4-dihydro-1,8-naphthyridin-1-yl}-N-[3-(methylsulfanyl)phenyl]acetamide
L859-0354 Screening compound: 2-{7-methyl-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]-4-oxo-1,4-dihydro-1,8-naphthyridin-1-yl}-N-[3-(methylsulfanyl)phenyl]acetamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L859-0354
2-{7-methyl-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]-4-oxo-1,4-dihydro-1,8-naphthyridin-1-yl}-N-[3-(methylsulfanyl)phenyl]acetamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L859-0354

Molecular Formula

C27H23N5O3S (C27 H23 N5 O3 S)

Compound Name

2-{7-methyl-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]-4-oxo-1,4-dihydro-1,8-naphthyridin-1-yl}-N-[3-(methylsulfanyl)phenyl]acetamide

IUPAC name

2-{7-methyl-3-[3-(2-methylphenyl)-124-oxadiazol-5-yl]-4-oxo-14-dihydro-18-naphthyridin-1-yl}-N-[3-(methylsulfanyl)phenyl]acetamide

SMILES

Cc(cccc1)c1-c1noc(C2=CN(CC(Nc3cccc(SC)c3)=O)c3nc(C)ccc3C2=O)n1

InChI

InChI=1S/C27H23N5O3S/c1-16-7-4-5-10-20(16)25-30-27(35-31-25)22-14-32(26-21(24(22)34)12-11-17(2)28-26)15-23(33)29-18-8-6-9-19(13-18)36-3/h4-14H,15H2,1-3H3,(H,29,33)

InChI Key

RBDSXELTUKQIPO-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD20754193

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

497.58

Hydrogen Bond Acceptors Count

9.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

5.632

Distribution Coefficient, logD

5.632

Water Solubility, LogSw

-5.44

Polar Surface Area

79.823

Acid Dissociation Constant (pKa)

12.61

Base Dissociation Constant (pKb)

0.96

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

14.80

L859-0354 in Drug Discovery

Included in Screening Libraries

Adenosine Receptors Targeted Library (19896 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Nervous system
  • Eye
  • Cardiovascular
Targets:
  • GPCR
Mechanism of action:
  • Receptor's ligands

References: we are preparing a list of scientific research reports with L859-0354 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L859-0354?
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What is the minimum amount of L859-0354 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L859-0354
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L859-0354
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L859-0354 available by request