L888-0183 Screening compound: 4-methyl-3-{1-methyl-5-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-3-yl}-5-(methylsulfanyl)-4H-1,2,4-triazole

L888-0183 Screening compound: 4-methyl-3-{1-methyl-5-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-3-yl}-5-(methylsulfanyl)-4H-1,2,4-triazole
L888-0183 Screening compound: 4-methyl-3-{1-methyl-5-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-3-yl}-5-(methylsulfanyl)-4H-1,2,4-triazole alternative view

Chemical Structure Depiction of ChemDiv screening compound L888-0183
4-methyl-3-{1-methyl-5-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-3-yl}-5-(methylsulfanyl)-4H-1,2,4-triazole

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L888-0183

Molecular Formula

C17H24N8O2S2 (C17 H24 N8 O2 S2)

Compound Name

4-methyl-3-{1-methyl-5-[(1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl]-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-3-yl}-5-(methylsulfanyl)-4H-1,2,4-triazole

IUPAC name

4-methyl-3-{1-methyl-5-[(135-trimethyl-1H-pyrazol-4-yl)sulfonyl]-1H4H5H6H7H-pyrazolo[43-c]pyridin-3-yl}-5-(methylsulfanyl)-4H-124-triazole

SMILES

Cc(n(C)nc1C)c1S(N(CC1)Cc2c1n(C)nc2-c(n1C)nnc1SC)(=O)=O

InChI

InChI=1S/C17H24N8O2S2/c1-10-15(11(2)23(4)20-10)29(26,27)25-8-7-13-12(9-25)14(21-24(13)5)16-18-19-17(28-6)22(16)3/h7-9H2,1-6H3

InChI Key

AAHNQPKPVFFCLT-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD15136293

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

436.56

Hydrogen Bond Acceptors Count

10.00

Hydrogen Bond Donors Count

0.00

Rotatable Bond Count

4.00

Number of Nitrogen and Oxygen Atoms

10

Partition Coefficient, logP

-0.352

Distribution Coefficient, logD

-0.356

Water Solubility, LogSw

-0.78

Polar Surface Area

86.552

Acid Dissociation Constant (pKa)

22.25

Base Dissociation Constant (pKb)

5.40

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

52.90

L888-0183 in Drug Discovery

Included in Screening Libraries

Protein Arginine Methyltransferases Library (27925 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Metabolic
Targets:
  • Others
Mechanism of action:
  • Epigenetic

References: we are preparing a list of scientific research reports with L888-0183 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L888-0183?
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What is the minimum amount of L888-0183 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L888-0183
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L888-0183
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L888-0183 available by request