L933-0356 Screening compound: 3-(1-{4-benzyl-3-oxo-3H,4H-pyrido[2,3-b]pyrazin-2-yl}piperidin-4-yl)-1-(2,4-difluorophenyl)urea

L933-0356 Screening compound: 3-(1-{4-benzyl-3-oxo-3H,4H-pyrido[2,3-b]pyrazin-2-yl}piperidin-4-yl)-1-(2,4-difluorophenyl)urea
L933-0356 Screening compound: 3-(1-{4-benzyl-3-oxo-3H,4H-pyrido[2,3-b]pyrazin-2-yl}piperidin-4-yl)-1-(2,4-difluorophenyl)urea alternative view

Chemical Structure Depiction of ChemDiv screening compound L933-0356
3-(1-{4-benzyl-3-oxo-3H,4H-pyrido[2,3-b]pyrazin-2-yl}piperidin-4-yl)-1-(2,4-difluorophenyl)urea

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L933-0356

Molecular Formula

C26H24F2N6O2 (C26 H24 F2 N6 O2)

Compound Name

3-(1-{4-benzyl-3-oxo-3H,4H-pyrido[2,3-b]pyrazin-2-yl}piperidin-4-yl)-1-(2,4-difluorophenyl)urea

IUPAC name

3-(1-{4-benzyl-3-oxo-3H4H-pyrido[23-b]pyrazin-2-yl}piperidin-4-yl)-1-(24-difluorophenyl)urea

SMILES

O=C(NC(CC1)CCN1C(C(N1Cc2ccccc2)=O)=Nc2c1nccc2)Nc(ccc(F)c1)c1F

InChI

InChI=1S/C26H24F2N6O2/c27-18-8-9-21(20(28)15-18)32-26(36)30-19-10-13-33(14-11-19)24-25(35)34(16-17-5-2-1-3-6-17)23-22(31-24)7-4-12-29-23/h1-9,12,15,19H,10-11,13-14,16H2,(H2,30,32,36)

InChI Key

HVPNJSLWUSTKHV-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27488195

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

490.51

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

3.407

Distribution Coefficient, logD

3.407

Water Solubility, LogSw

-3.75

Polar Surface Area

69.011

Acid Dissociation Constant (pKa)

10.58

Base Dissociation Constant (pKb)

3.04

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

23.10

L933-0356 in Drug Discovery

Included in Screening Libraries

Chelators targeting matrix metalloproteinases library (8930 compounds)

Akt-Targeted Library (14764 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Cardiovascular
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Proteases
  • Kinases

References: we are preparing a list of scientific research reports with L933-0356 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L933-0356?
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What is the minimum amount of L933-0356 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L933-0356
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L933-0356
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L933-0356 available by request