L933-0463 Screening compound: 1-(5-chloro-2-methoxyphenyl)-3-{1-[3-oxo-4-(prop-2-en-1-yl)-3H,4H-pyrido[2,3-b]pyrazin-2-yl]piperidin-4-yl}urea

L933-0463 Screening compound: 1-(5-chloro-2-methoxyphenyl)-3-{1-[3-oxo-4-(prop-2-en-1-yl)-3H,4H-pyrido[2,3-b]pyrazin-2-yl]piperidin-4-yl}urea
L933-0463 Screening compound: 1-(5-chloro-2-methoxyphenyl)-3-{1-[3-oxo-4-(prop-2-en-1-yl)-3H,4H-pyrido[2,3-b]pyrazin-2-yl]piperidin-4-yl}urea alternative view

Chemical Structure Depiction of ChemDiv screening compound L933-0463
1-(5-chloro-2-methoxyphenyl)-3-{1-[3-oxo-4-(prop-2-en-1-yl)-3H,4H-pyrido[2,3-b]pyrazin-2-yl]piperidin-4-yl}urea

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L933-0463

Molecular Formula

C23H25ClN6O3 (C23 H25 ClN6 O3)

Compound Name

1-(5-chloro-2-methoxyphenyl)-3-{1-[3-oxo-4-(prop-2-en-1-yl)-3H,4H-pyrido[2,3-b]pyrazin-2-yl]piperidin-4-yl}urea

IUPAC name

1-(5-chloro-2-methoxyphenyl)-3-{1-[3-oxo-4-(prop-2-en-1-yl)-3H4H-pyrido[23-b]pyrazin-2-yl]piperidin-4-yl}urea

SMILES

COc(ccc(Cl)c1)c1NC(NC(CC1)CCN1C(C(N1CC=C)=O)=Nc2c1nccc2)=O

InChI

InChI=1S/C23H25ClN6O3/c1-3-11-30-20-17(5-4-10-25-20)27-21(22(30)31)29-12-8-16(9-13-29)26-23(32)28-18-14-15(24)6-7-19(18)33-2/h3-7,10,14,16H,1,8-9,11-13H2,2H3,(H2,26,28,32)

InChI Key

CIJVOZOVFRJHPE-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27488259

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

468.94

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

2.00

Rotatable Bond Count

8.00

Number of Nitrogen and Oxygen Atoms

9

Partition Coefficient, logP

2.628

Distribution Coefficient, logD

2.628

Water Solubility, LogSw

-3.43

Polar Surface Area

76.892

Acid Dissociation Constant (pKa)

10.94

Base Dissociation Constant (pKb)

4.12

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

30.40

L933-0463 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

Chelators targeting matrix metalloproteinases library (8930 compounds)

Anti-HIV1 Library (19540 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Cardiovascular
  • Antiviral
  • Infections
  • Immune system
Targets:
  • Proteases

References: we are preparing a list of scientific research reports with L933-0463 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L933-0463?
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What is the minimum amount of L933-0463 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L933-0463
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L933-0463
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L933-0463 available by request