L949-3154 Screening compound: 2-[3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-N-(3,5-dimethylphenyl)pyrrolidine-1-carboxamide

L949-3154 Screening compound: 2-[3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-N-(3,5-dimethylphenyl)pyrrolidine-1-carboxamide
L949-3154 Screening compound: 2-[3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-N-(3,5-dimethylphenyl)pyrrolidine-1-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound L949-3154
2-[3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-N-(3,5-dimethylphenyl)pyrrolidine-1-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L949-3154

Molecular Formula

C21H20F2N4O2 (C21 H20 F2 N4 O2)

Compound Name

2-[3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-N-(3,5-dimethylphenyl)pyrrolidine-1-carboxamide

IUPAC name

2-[3-(24-difluorophenyl)-124-oxadiazol-5-yl]-N-(35-dimethylphenyl)pyrrolidine-1-carboxamide

SMILES

Cc1cc(NC(N(CCC2)C2c2nc(-c(ccc(F)c3)c3F)no2)=O)cc(C)c1

InChI

InChI=1S/C21H20F2N4O2/c1-12-8-13(2)10-15(9-12)24-21(28)27-7-3-4-18(27)20-25-19(26-29-20)16-6-5-14(22)11-17(16)23/h5-6,8-11,18H,3-4,7H2,1-2H3,(H,24,28)/t18-/m0/s1

InChI Key

LIOQTPCHCRKGOK-SFHVURJKSA-N

MDL Number (MFCD)

MFCD27489415

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

398.41

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

6

Partition Coefficient, logP

4.886

Distribution Coefficient, logD

4.886

Water Solubility, LogSw

-4.59

Polar Surface Area

57.173

Acid Dissociation Constant (pKa)

14.89

Base Dissociation Constant (pKb)

0.11

Number of Chiral Centers

1.00

Percent sp3 carbon bonding

28.60

L949-3154 in Drug Discovery

Included in Screening Libraries

Angiogenesis library (14822 compounds)

Protein-Protein Interaction Library (218420 compounds)

Serine Proteases Inhibitors Library (32732 compounds)

SmartTM Library (51161 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Infections
  • Cancer
  • Musculoskeletal
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Cardiovascular
  • Skin
  • Metabolic
  • Immune system
Mechanism of action:
  • PPI modulators
Targets:
  • Proteases
Structure:
  • Cyclic compounds

References: we are preparing a list of scientific research reports with L949-3154 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L949-3154?
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What is the minimum amount of L949-3154 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L949-3154
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L949-3154
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L949-3154 available by request