L967-0403 Screening compound: methyl 4-{[2-chloro-5-(trifluoromethyl)phenyl]amino}-7-methyl-1,8-naphthyridine-3-carboxylate

L967-0403 Screening compound: methyl 4-{[2-chloro-5-(trifluoromethyl)phenyl]amino}-7-methyl-1,8-naphthyridine-3-carboxylate
L967-0403 Screening compound: methyl 4-{[2-chloro-5-(trifluoromethyl)phenyl]amino}-7-methyl-1,8-naphthyridine-3-carboxylate alternative view

Chemical Structure Depiction of ChemDiv screening compound L967-0403
methyl 4-{[2-chloro-5-(trifluoromethyl)phenyl]amino}-7-methyl-1,8-naphthyridine-3-carboxylate

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

L967-0403

Molecular Formula

C18H13ClF3N3O2 (C18 H13 ClF3 N3 O2)

Compound Name

methyl 4-{[2-chloro-5-(trifluoromethyl)phenyl]amino}-7-methyl-1,8-naphthyridine-3-carboxylate

IUPAC name

methyl 4-{[2-chloro-5-(trifluoromethyl)phenyl]amino}-7-methyl-18-naphthyridine-3-carboxylate

SMILES

Cc1ccc(c(Nc(cc(C(F)(F)F)cc2)c2Cl)c(cn2)C(OC)=O)c2n1

InChI

InChI=1S/C18H13ClF3N3O2/c1-9-3-5-11-15(12(17(26)27-2)8-23-16(11)24-9)25-14-7-10(18(20,21)22)4-6-13(14)19/h3-8H,1-2H3,(H,23,24,25)

InChI Key

PFISFYMEHWTRCQ-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27490254

Chemical and Physical Properties

Saltdata

HCl

Molecular Weight

395.77

Hydrogen Bond Acceptors Count

5.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

5.00

Number of Nitrogen and Oxygen Atoms

5

Partition Coefficient, logP

5.112

Distribution Coefficient, logD

5.112

Water Solubility, LogSw

-5.53

Polar Surface Area

46.832

Acid Dissociation Constant (pKa)

11.55

Base Dissociation Constant (pKb)

4.48

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

16.70

L967-0403 in Drug Discovery

Included in Screening Libraries

300k Representative Compounds Library (Bemis-Murcko Clustering Algorithm) (286253 compounds)

PI3K-Targeted Library (17255 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Otorhinolaryngologic
  • Male
  • Female
  • Hemic and lymphatic
  • Skin
Targets:
  • Kinases

References: we are preparing a list of scientific research reports with L967-0403 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound L967-0403?
Check Price and Availability of L967-0403, then you can add required amount to the Shopping Cart. In the Shopping Cart you can again refine your selection. Once you are sure that it’s exactly what you want you can move forward with the Checkout (to pay online by credit card, or via PayPal), or Request a Quote.
What is the minimum amount of L967-0403 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for L967-0403
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for L967-0403
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of L967-0403 available by request