M136-0359 Screening compound: 1-{3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}-N-[(furan-2-yl)methyl]piperidine-4-carboxamide

M136-0359 Screening compound: 1-{3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}-N-[(furan-2-yl)methyl]piperidine-4-carboxamide
M136-0359 Screening compound: 1-{3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}-N-[(furan-2-yl)methyl]piperidine-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound M136-0359
1-{3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}-N-[(furan-2-yl)methyl]piperidine-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

M136-0359

Molecular Formula

C24H22ClN5O3 (C24 H22 ClN5 O3)

Compound Name

1-{3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}-N-[(furan-2-yl)methyl]piperidine-4-carboxamide

IUPAC name

1-{3-[3-(4-chlorophenyl)-124-oxadiazol-5-yl]pyridin-2-yl}-N-[(furan-2-yl)methyl]piperidine-4-carboxamide

SMILES

O=C(C(CC1)CCN1c(nccc1)c1-c1nc(-c(cc2)ccc2Cl)no1)NCc1ccco1

InChI

InChI=1S/C24H22ClN5O3/c25-18-7-5-16(6-8-18)21-28-24(33-29-21)20-4-1-11-26-22(20)30-12-9-17(10-13-30)23(31)27-15-19-3-2-14-32-19/h1-8,11,14,17H,9-10,12-13,15H2,(H,27,31)

InChI Key

FUFULFZBJOUSEA-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27532124

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

463.92

Hydrogen Bond Acceptors Count

7.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

8

Partition Coefficient, logP

4.839

Distribution Coefficient, logD

4.829

Water Solubility, LogSw

-5.12

Polar Surface Area

76.240

Acid Dissociation Constant (pKa)

12.38

Base Dissociation Constant (pKb)

5.77

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

25.00

M136-0359 in Drug Discovery

Included in Screening Libraries

CNS Targets (44014 compounds)

Hsp90-Targeted Library (11355 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Nonpeptide Peptidomimetics PPI Library (18997 compounds)

Protein-Protein Interaction Library (218420 compounds)

SmartTM Library (51161 compounds)

Adenosine Receptors Targeted Library (19896 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Nervous system
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system
  • Hemic and lymphatic
  • Cardiovascular
  • Cancer
  • Digestive system
  • Respiratory tract
  • Nervous system
  • Eye
  • Cardiovascular
Mechanism of action:
  • PPI modulators
  • PPI modulators
  • Receptor's ligands
Structure:
  • Mimetics
Targets:
  • GPCR

References: we are preparing a list of scientific research reports with M136-0359 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound M136-0359?
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What is the minimum amount of M136-0359 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for M136-0359
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for M136-0359
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of M136-0359 available by request