M136-0526 Screening compound: 1-{3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}-N-(2-methylpropyl)piperidine-4-carboxamide

M136-0526 Screening compound: 1-{3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}-N-(2-methylpropyl)piperidine-4-carboxamide
M136-0526 Screening compound: 1-{3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}-N-(2-methylpropyl)piperidine-4-carboxamide alternative view

Chemical Structure Depiction of ChemDiv screening compound M136-0526
1-{3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}-N-(2-methylpropyl)piperidine-4-carboxamide

Available from 1 mg

Formats:

  • Glass Vials (4ml Glass Vials VWR #97047-678)
  • 96-tube racks (Matrix #4247 96-well 1.4ml sealed with capmats, empty cols 1 & 12, 100uL of 10mM)

Shiptime: 1 week worldwide delivery in most cases

Compound Identifiers

ChemDiv Compound ID

M136-0526

Molecular Formula

C24H29N5O2 (C24 H29 N5 O2)

Compound Name

1-{3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]pyridin-2-yl}-N-(2-methylpropyl)piperidine-4-carboxamide

IUPAC name

1-{3-[3-(4-methylphenyl)-124-oxadiazol-5-yl]pyridin-2-yl}-N-(2-methylpropyl)piperidine-4-carboxamide

SMILES

CC(C)CNC(C(CC1)CCN1c1ncccc1-c1nc(-c2ccc(C)cc2)no1)=O

InChI

InChI=1S/C24H29N5O2/c1-16(2)15-26-23(30)19-10-13-29(14-11-19)22-20(5-4-12-25-22)24-27-21(28-31-24)18-8-6-17(3)7-9-18/h4-9,12,16,19H,10-11,13-15H2,1-3H3,(H,26,30)

InChI Key

KUKXBRANLABMPI-UHFFFAOYSA-N

MDL Number (MFCD)

MFCD27532136

Chemical and Physical Properties

Saltdata

n/a

Molecular Weight

419.53

Hydrogen Bond Acceptors Count

6.00

Hydrogen Bond Donors Count

1.00

Rotatable Bond Count

7.00

Number of Nitrogen and Oxygen Atoms

7

Partition Coefficient, logP

4.827

Distribution Coefficient, logD

4.817

Water Solubility, LogSw

-4.35

Polar Surface Area

68.762

Acid Dissociation Constant (pKa)

15.47

Base Dissociation Constant (pKb)

5.77

Number of Chiral Centers

0.00

Percent sp3 carbon bonding

41.70

M136-0526 in Drug Discovery

Included in Screening Libraries

Hsp90-Targeted Library (11355 compounds)

Macl-GPIb alpha Interaction Library (22969 compounds)

Nonpeptide Peptidomimetics PPI Library (18997 compounds)

Protein-Protein Interaction Library (218420 compounds)

Beyond the Flatland Library sp3 enriched (92988 compounds)

Included in 1.7M Stock Database

Therapeutical areas:
  • Cancer
  • Digestive system
  • Respiratory tract
  • Male
  • Female
  • Hemic and lymphatic
  • Immune system
  • Hemic and lymphatic
  • Cardiovascular
Mechanism of action:
  • PPI modulators
  • PPI modulators
Structure:
  • Mimetics
  • Cyclic compounds

References: we are preparing a list of scientific research reports with M136-0526 chemical compound. It will be published here after verification.

Frequently Asked Questions

How to purchase chemical compound M136-0526?
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What is the minimum amount of M136-0526 you sell to drug discovery company or institution?
Available from 1 mg in Glass Vials or 96-tube racks.
Delivery options for M136-0526
ChemDiv sends parcels with Express services (UPS, WC).
  • 1–2 days for small orders
  • 2–4 weeks for large selections
Delivery formats for M136-0526
  • 0.5–50 mg of dry powder sample in single glass vials, custom vials
  • DMSO solutions frozen 10μl–250μl@10mM (96 and 384 format)

Custom synthesis of M136-0526 available by request